Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans

BACKGROUND: Chagas disease (CD) is a tropical parasitic disease. Although the number of people infected is very high, the only drugs available to treat CD, nifurtimox (Nfx) and benznidazole, are highly toxic, particularly in the chronic stage of the disease. Coumarins are a large class of compounds...

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Detalles Bibliográficos
Autores principales: Soares, Fabiana Gomes Nascimento, Göethel, Gabriela, Kagami, Luciano Porto, das Neves, Gustavo Machado, Sauer, Elisa, Birriel, Estefania, Varela, Javier, Gonçalves, Itamar Luís, Von Poser, Gilsane, González, Mercedes, Kawano, Daniel Fábio, Paula, Fávero Reisdorfer, de Melo, Eduardo Borges, Garcia, Solange Cristina, Cerecetto, Hugo, Eifler-Lima, Vera Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921407/
https://www.ncbi.nlm.nih.gov/pubmed/31852548
http://dx.doi.org/10.1186/s40360-019-0357-z

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