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Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

BACKGROUND: The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represents an e...

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Detalles Bibliográficos
Autores principales:	Jenkins, Timothy G., James, Emma R., Aston, Kenneth I., Salas-Huetos, Albert, Pastuszak, Alexander W., Smith, Ken R., Hanson, Heidi A., Hotaling, James M., Carrell, Douglas T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921445/ https://www.ncbi.nlm.nih.gov/pubmed/31856899 http://dx.doi.org/10.1186/s13072-019-0323-4

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