Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice

BACKGROUND: β(2) receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (Epac) was identified as another important signaling molecule of cAMP recent...

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Detalles Bibliográficos
Autores principales: Chen, Yi-fei, Huang, Ge, Wang, Yi-min, Cheng, Ming, Zhu, Fang-fang, Zhong, Jin-nan, Gao, Ya-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921488/
https://www.ncbi.nlm.nih.gov/pubmed/31852500
http://dx.doi.org/10.1186/s12931-019-1260-2

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