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Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls

BACKGROUND: Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intak...

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Detalles Bibliográficos
Autores principales: Xu, Yueqin, Li, Yan, Liang, Shuang, Li, Guimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921498/
https://www.ncbi.nlm.nih.gov/pubmed/31856872
http://dx.doi.org/10.1186/s13052-019-0758-z
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author Xu, Yueqin
Li, Yan
Liang, Shuang
Li, Guimei
author_facet Xu, Yueqin
Li, Yan
Liang, Shuang
Li, Guimei
author_sort Xu, Yueqin
collection PubMed
description BACKGROUND: Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intake, insulin resistance and lipid profile with PT. METHODS: Two hundred sixty-three girls with PT, and 222 healthy girls of similar age were enrolled into this study. Their demographics, Tanner stage of breast development, nutrient intake, insulin resistance and lipid profiles were compared. RESULTS: Daily protein and fat intakes, insulin resistance parameters including serum insulin-like growth factor 1, fasting glucose to insulin ratio, quantitative insulin check index and homeostasis model of assessment of insulin resistance, as well as serum levels of triacylglycerol, total cholesterol and low-density lipoprotein, were all significantly altered in PT patients. Daily intake of energy and carbohydrate, and serum level of high-density lipoprotein protein were statistically indistinguishable between PT patients and healthy controls. CONCLUSION: Chinese girls with PT are potentially insulin resistant, which warrants more clinical attention and further investigation to address the underlying etiology.
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spelling pubmed-69214982019-12-30 Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls Xu, Yueqin Li, Yan Liang, Shuang Li, Guimei Ital J Pediatr Research BACKGROUND: Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intake, insulin resistance and lipid profile with PT. METHODS: Two hundred sixty-three girls with PT, and 222 healthy girls of similar age were enrolled into this study. Their demographics, Tanner stage of breast development, nutrient intake, insulin resistance and lipid profiles were compared. RESULTS: Daily protein and fat intakes, insulin resistance parameters including serum insulin-like growth factor 1, fasting glucose to insulin ratio, quantitative insulin check index and homeostasis model of assessment of insulin resistance, as well as serum levels of triacylglycerol, total cholesterol and low-density lipoprotein, were all significantly altered in PT patients. Daily intake of energy and carbohydrate, and serum level of high-density lipoprotein protein were statistically indistinguishable between PT patients and healthy controls. CONCLUSION: Chinese girls with PT are potentially insulin resistant, which warrants more clinical attention and further investigation to address the underlying etiology. BioMed Central 2019-12-19 /pmc/articles/PMC6921498/ /pubmed/31856872 http://dx.doi.org/10.1186/s13052-019-0758-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Xu, Yueqin
Li, Yan
Liang, Shuang
Li, Guimei
Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
title Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
title_full Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
title_fullStr Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
title_full_unstemmed Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
title_short Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
title_sort differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche chinese girls
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921498/
https://www.ncbi.nlm.nih.gov/pubmed/31856872
http://dx.doi.org/10.1186/s13052-019-0758-z
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