Cargando…
Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls
BACKGROUND: Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intak...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921498/ https://www.ncbi.nlm.nih.gov/pubmed/31856872 http://dx.doi.org/10.1186/s13052-019-0758-z |
_version_ | 1783481174036840448 |
---|---|
author | Xu, Yueqin Li, Yan Liang, Shuang Li, Guimei |
author_facet | Xu, Yueqin Li, Yan Liang, Shuang Li, Guimei |
author_sort | Xu, Yueqin |
collection | PubMed |
description | BACKGROUND: Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intake, insulin resistance and lipid profile with PT. METHODS: Two hundred sixty-three girls with PT, and 222 healthy girls of similar age were enrolled into this study. Their demographics, Tanner stage of breast development, nutrient intake, insulin resistance and lipid profiles were compared. RESULTS: Daily protein and fat intakes, insulin resistance parameters including serum insulin-like growth factor 1, fasting glucose to insulin ratio, quantitative insulin check index and homeostasis model of assessment of insulin resistance, as well as serum levels of triacylglycerol, total cholesterol and low-density lipoprotein, were all significantly altered in PT patients. Daily intake of energy and carbohydrate, and serum level of high-density lipoprotein protein were statistically indistinguishable between PT patients and healthy controls. CONCLUSION: Chinese girls with PT are potentially insulin resistant, which warrants more clinical attention and further investigation to address the underlying etiology. |
format | Online Article Text |
id | pubmed-6921498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69214982019-12-30 Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls Xu, Yueqin Li, Yan Liang, Shuang Li, Guimei Ital J Pediatr Research BACKGROUND: Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intake, insulin resistance and lipid profile with PT. METHODS: Two hundred sixty-three girls with PT, and 222 healthy girls of similar age were enrolled into this study. Their demographics, Tanner stage of breast development, nutrient intake, insulin resistance and lipid profiles were compared. RESULTS: Daily protein and fat intakes, insulin resistance parameters including serum insulin-like growth factor 1, fasting glucose to insulin ratio, quantitative insulin check index and homeostasis model of assessment of insulin resistance, as well as serum levels of triacylglycerol, total cholesterol and low-density lipoprotein, were all significantly altered in PT patients. Daily intake of energy and carbohydrate, and serum level of high-density lipoprotein protein were statistically indistinguishable between PT patients and healthy controls. CONCLUSION: Chinese girls with PT are potentially insulin resistant, which warrants more clinical attention and further investigation to address the underlying etiology. BioMed Central 2019-12-19 /pmc/articles/PMC6921498/ /pubmed/31856872 http://dx.doi.org/10.1186/s13052-019-0758-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Xu, Yueqin Li, Yan Liang, Shuang Li, Guimei Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls |
title | Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls |
title_full | Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls |
title_fullStr | Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls |
title_full_unstemmed | Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls |
title_short | Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls |
title_sort | differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche chinese girls |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921498/ https://www.ncbi.nlm.nih.gov/pubmed/31856872 http://dx.doi.org/10.1186/s13052-019-0758-z |
work_keys_str_mv | AT xuyueqin differentialanalysisofnutrientintakeinsulinresistanceandlipidprofilesbetweenhealthyandprematurethelarchechinesegirls AT liyan differentialanalysisofnutrientintakeinsulinresistanceandlipidprofilesbetweenhealthyandprematurethelarchechinesegirls AT liangshuang differentialanalysisofnutrientintakeinsulinresistanceandlipidprofilesbetweenhealthyandprematurethelarchechinesegirls AT liguimei differentialanalysisofnutrientintakeinsulinresistanceandlipidprofilesbetweenhealthyandprematurethelarchechinesegirls |