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Genome-wide association study of morbid obesity in Han Chinese
BACKGROUND: As obesity is becoming pandemic, morbid obesity (MO), an extreme type of obesity, is an emerging issue worldwide. It is imperative to understand the factors responsible for huge weight gain in certain populations in the modern society. Very few genome-wide association studies (GWAS) have...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921553/ https://www.ncbi.nlm.nih.gov/pubmed/31852448 http://dx.doi.org/10.1186/s12863-019-0797-x |
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author | Chiang, Kuang-Mao Chang, Heng-Cheng Yang, Hsin-Chou Chen, Chien-Hsiun Chen, Hsin-Hung Lee, Wei-Jei Pan, Wen-Harn |
author_facet | Chiang, Kuang-Mao Chang, Heng-Cheng Yang, Hsin-Chou Chen, Chien-Hsiun Chen, Hsin-Hung Lee, Wei-Jei Pan, Wen-Harn |
author_sort | Chiang, Kuang-Mao |
collection | PubMed |
description | BACKGROUND: As obesity is becoming pandemic, morbid obesity (MO), an extreme type of obesity, is an emerging issue worldwide. It is imperative to understand the factors responsible for huge weight gain in certain populations in the modern society. Very few genome-wide association studies (GWAS) have been conducted on MO patients. This study is the first MO-GWAS study in the Han-Chinese population in Asia. METHODS: We conducted a two-stage GWAS with 1110 MO bariatric patients (body mass index [BMI] ≥ 35 kg/m(2)) from Min-Sheng General Hospital, Taiwan. The first stage involved 575 patients, and 1729 sex- and age-matched controls from the Taiwan Han Chinese Cell and Genome Bank. In the second stage, another 535 patients from the same hospital were genotyped for 52 single nucleotide polymorphisms (SNPs) discovered in the first stage, and 9145 matched controls from Taiwan Biobank were matched for confirmation analysis. RESULTS: The results of the joint analysis for the second stage revealed six top ranking SNPs, including rs8050136 (p-value = 7.80 × 10(− 10)), rs9939609 (p-value = 1.32 × 10(− 9)), rs1421085 (p-value = 1.54 × 10(− 8)), rs9941349 (p-value = 9.05 × 10(− 8)), rs1121980 (p-value = 7.27 × 10(− 7)), and rs9937354 (p-value = 6.65 × 10(− 7)), which were all located in FTO gene. Significant associations were also observed between MO and RBFOX1, RP11-638 L3.1, TMTC1, CBLN4, CSMD3, and ERBB4, respectively, using the Bonferroni correction criteria for 52 SNPs (p < 9.6 × 10(− 4)). CONCLUSION: The most significantly associated locus of MO in the Han-Chinese population was the well-known FTO gene. These SNPs located in intron 1, may include the leptin receptor modulator. Other significant loci, showing weak associations with MO, also suggested the potential mechanism underlying the disorders with eating behaviors or brain/neural development. |
format | Online Article Text |
id | pubmed-6921553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69215532019-12-30 Genome-wide association study of morbid obesity in Han Chinese Chiang, Kuang-Mao Chang, Heng-Cheng Yang, Hsin-Chou Chen, Chien-Hsiun Chen, Hsin-Hung Lee, Wei-Jei Pan, Wen-Harn BMC Genet Research Article BACKGROUND: As obesity is becoming pandemic, morbid obesity (MO), an extreme type of obesity, is an emerging issue worldwide. It is imperative to understand the factors responsible for huge weight gain in certain populations in the modern society. Very few genome-wide association studies (GWAS) have been conducted on MO patients. This study is the first MO-GWAS study in the Han-Chinese population in Asia. METHODS: We conducted a two-stage GWAS with 1110 MO bariatric patients (body mass index [BMI] ≥ 35 kg/m(2)) from Min-Sheng General Hospital, Taiwan. The first stage involved 575 patients, and 1729 sex- and age-matched controls from the Taiwan Han Chinese Cell and Genome Bank. In the second stage, another 535 patients from the same hospital were genotyped for 52 single nucleotide polymorphisms (SNPs) discovered in the first stage, and 9145 matched controls from Taiwan Biobank were matched for confirmation analysis. RESULTS: The results of the joint analysis for the second stage revealed six top ranking SNPs, including rs8050136 (p-value = 7.80 × 10(− 10)), rs9939609 (p-value = 1.32 × 10(− 9)), rs1421085 (p-value = 1.54 × 10(− 8)), rs9941349 (p-value = 9.05 × 10(− 8)), rs1121980 (p-value = 7.27 × 10(− 7)), and rs9937354 (p-value = 6.65 × 10(− 7)), which were all located in FTO gene. Significant associations were also observed between MO and RBFOX1, RP11-638 L3.1, TMTC1, CBLN4, CSMD3, and ERBB4, respectively, using the Bonferroni correction criteria for 52 SNPs (p < 9.6 × 10(− 4)). CONCLUSION: The most significantly associated locus of MO in the Han-Chinese population was the well-known FTO gene. These SNPs located in intron 1, may include the leptin receptor modulator. Other significant loci, showing weak associations with MO, also suggested the potential mechanism underlying the disorders with eating behaviors or brain/neural development. BioMed Central 2019-12-18 /pmc/articles/PMC6921553/ /pubmed/31852448 http://dx.doi.org/10.1186/s12863-019-0797-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Chiang, Kuang-Mao Chang, Heng-Cheng Yang, Hsin-Chou Chen, Chien-Hsiun Chen, Hsin-Hung Lee, Wei-Jei Pan, Wen-Harn Genome-wide association study of morbid obesity in Han Chinese |
title | Genome-wide association study of morbid obesity in Han Chinese |
title_full | Genome-wide association study of morbid obesity in Han Chinese |
title_fullStr | Genome-wide association study of morbid obesity in Han Chinese |
title_full_unstemmed | Genome-wide association study of morbid obesity in Han Chinese |
title_short | Genome-wide association study of morbid obesity in Han Chinese |
title_sort | genome-wide association study of morbid obesity in han chinese |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921553/ https://www.ncbi.nlm.nih.gov/pubmed/31852448 http://dx.doi.org/10.1186/s12863-019-0797-x |
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