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Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report

BACKGROUND: Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medicine have been scarse. Moreover, only one case of intradural extramedullary IPT h...

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Autores principales: Yamashita, Masamichi, Osaki, Tomohiro, Murahata, Yusuke, Sunden, Yuji, Morita, Rinko, Imagawa, Tomohiro, Okamoto, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921595/
https://www.ncbi.nlm.nih.gov/pubmed/31856853
http://dx.doi.org/10.1186/s12917-019-2213-1
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author Yamashita, Masamichi
Osaki, Tomohiro
Murahata, Yusuke
Sunden, Yuji
Morita, Rinko
Imagawa, Tomohiro
Okamoto, Yoshiharu
author_facet Yamashita, Masamichi
Osaki, Tomohiro
Murahata, Yusuke
Sunden, Yuji
Morita, Rinko
Imagawa, Tomohiro
Okamoto, Yoshiharu
author_sort Yamashita, Masamichi
collection PubMed
description BACKGROUND: Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medicine have been scarse. Moreover, only one case of intradural extramedullary IPT has been previously reported. In this report, we introduce the first known case of canine IPT, which occurred in the parenchyma of the spinal cord. CASE PRESENTATION: A 10-year-old female Miniature Dachshund presented with a 2-month-long history of progressively worsening ataxia and tetraparesis. Neurological examination was consistent with a lesion involving the cervical spinal cord. Magnetic resonance imaging revealed an intradural space-occupying lesion in the region of the fourth cervical vertebra. Dorsal laminectomy and resection of the mass were performed. Histopathological examination revealed the proliferation of immature spindle cells (fibroblasts/myofibroblasts and glial cells) and a highly cellular mixture of neutrophils, macrophages and lymphocytic cells. The mass was located in the parenchyma of the spinal cord and was diagnosed as an IPT occurring in the parenchyma of the spinal cord. No causative pathogen was detected. The dog’s symptoms improved, during the first month after surgery. However, neurological symptoms, such as laboured breathing and dysuria, subsequently worsened and the dog died 42 days after surgery. CONCLUSIONS: The present study describes a canine case of IPT occurring in the parenchyma of the spinal cord. The diagnosis and determination of the site of the mass was difficult solely based on preoperative imaging in the present case. The outcome of this case was poorer than that observed in cases of canine extramedullary IPT and human intramedullary IPT, in which the patients exhibited recovery. The prognosis after surgical resection cannot be decided from the present case alone. However, patients should be monitored for potential serious complications and recurrence.
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spelling pubmed-69215952019-12-30 Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report Yamashita, Masamichi Osaki, Tomohiro Murahata, Yusuke Sunden, Yuji Morita, Rinko Imagawa, Tomohiro Okamoto, Yoshiharu BMC Vet Res Case Report BACKGROUND: Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medicine have been scarse. Moreover, only one case of intradural extramedullary IPT has been previously reported. In this report, we introduce the first known case of canine IPT, which occurred in the parenchyma of the spinal cord. CASE PRESENTATION: A 10-year-old female Miniature Dachshund presented with a 2-month-long history of progressively worsening ataxia and tetraparesis. Neurological examination was consistent with a lesion involving the cervical spinal cord. Magnetic resonance imaging revealed an intradural space-occupying lesion in the region of the fourth cervical vertebra. Dorsal laminectomy and resection of the mass were performed. Histopathological examination revealed the proliferation of immature spindle cells (fibroblasts/myofibroblasts and glial cells) and a highly cellular mixture of neutrophils, macrophages and lymphocytic cells. The mass was located in the parenchyma of the spinal cord and was diagnosed as an IPT occurring in the parenchyma of the spinal cord. No causative pathogen was detected. The dog’s symptoms improved, during the first month after surgery. However, neurological symptoms, such as laboured breathing and dysuria, subsequently worsened and the dog died 42 days after surgery. CONCLUSIONS: The present study describes a canine case of IPT occurring in the parenchyma of the spinal cord. The diagnosis and determination of the site of the mass was difficult solely based on preoperative imaging in the present case. The outcome of this case was poorer than that observed in cases of canine extramedullary IPT and human intramedullary IPT, in which the patients exhibited recovery. The prognosis after surgical resection cannot be decided from the present case alone. However, patients should be monitored for potential serious complications and recurrence. BioMed Central 2019-12-19 /pmc/articles/PMC6921595/ /pubmed/31856853 http://dx.doi.org/10.1186/s12917-019-2213-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Yamashita, Masamichi
Osaki, Tomohiro
Murahata, Yusuke
Sunden, Yuji
Morita, Rinko
Imagawa, Tomohiro
Okamoto, Yoshiharu
Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
title Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
title_full Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
title_fullStr Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
title_full_unstemmed Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
title_short Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
title_sort imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921595/
https://www.ncbi.nlm.nih.gov/pubmed/31856853
http://dx.doi.org/10.1186/s12917-019-2213-1
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