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Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection

The nematode Trichinella spiralis can cause immunoregulation during the early phase of infection. However, previous studies are still insufficient for a full understanding of this phenomenon and its underlying mechanism. In this study, immune cells and cytokine profiles of T. spiralis infected mice...

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Autores principales: Song, Yining, Xu, Jing, Wang, Xuelin, Yang, Yong, Bai, Xue, Pang, Jianda, Wang, Xinrui, Yu, Mingchuan, Liu, Mingyuan, Liu, Xiaolei, Sun, Shumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921962/
https://www.ncbi.nlm.nih.gov/pubmed/31855175
http://dx.doi.org/10.1051/parasite/2019074
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author Song, Yining
Xu, Jing
Wang, Xuelin
Yang, Yong
Bai, Xue
Pang, Jianda
Wang, Xinrui
Yu, Mingchuan
Liu, Mingyuan
Liu, Xiaolei
Sun, Shumin
author_facet Song, Yining
Xu, Jing
Wang, Xuelin
Yang, Yong
Bai, Xue
Pang, Jianda
Wang, Xinrui
Yu, Mingchuan
Liu, Mingyuan
Liu, Xiaolei
Sun, Shumin
author_sort Song, Yining
collection PubMed
description The nematode Trichinella spiralis can cause immunoregulation during the early phase of infection. However, previous studies are still insufficient for a full understanding of this phenomenon and its underlying mechanism. In this study, immune cells and cytokine profiles of T. spiralis infected mice were examined by Meso Scale Discovery (MSD) and flow cytometry. The MSD results of the spleen showed that Th1 immunity was inhibited from 6 h to 6 days post-infection (dpi) and the level of Th2 immune response was significantly increased at 6 dpi. The mesenteric lymph node showed a Th1/Th2 mixed immune response from 3 dpi to 6 dpi with a downtrend of Th1 at 6 dpi. Flow cytometry analysis showed that the proportion of Th1 cells of T cells was decreased significantly at 6 h after infection, the proportion of Th2 cells was markedly increased, indicating that Th1 immunity was significantly inhibited at 6 h after infection, and a hybrid immune response based on Th2 type was presented from 30 h to 6 dpi. The immunoregulation effects observed during this study have provided a better understanding of the development of the immune response induced by Trichinella infection.
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spelling pubmed-69219622020-01-06 Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection Song, Yining Xu, Jing Wang, Xuelin Yang, Yong Bai, Xue Pang, Jianda Wang, Xinrui Yu, Mingchuan Liu, Mingyuan Liu, Xiaolei Sun, Shumin Parasite Research Article The nematode Trichinella spiralis can cause immunoregulation during the early phase of infection. However, previous studies are still insufficient for a full understanding of this phenomenon and its underlying mechanism. In this study, immune cells and cytokine profiles of T. spiralis infected mice were examined by Meso Scale Discovery (MSD) and flow cytometry. The MSD results of the spleen showed that Th1 immunity was inhibited from 6 h to 6 days post-infection (dpi) and the level of Th2 immune response was significantly increased at 6 dpi. The mesenteric lymph node showed a Th1/Th2 mixed immune response from 3 dpi to 6 dpi with a downtrend of Th1 at 6 dpi. Flow cytometry analysis showed that the proportion of Th1 cells of T cells was decreased significantly at 6 h after infection, the proportion of Th2 cells was markedly increased, indicating that Th1 immunity was significantly inhibited at 6 h after infection, and a hybrid immune response based on Th2 type was presented from 30 h to 6 dpi. The immunoregulation effects observed during this study have provided a better understanding of the development of the immune response induced by Trichinella infection. EDP Sciences 2019-12-19 /pmc/articles/PMC6921962/ /pubmed/31855175 http://dx.doi.org/10.1051/parasite/2019074 Text en © Y. Song et al., published by EDP Sciences, 2019 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Song, Yining
Xu, Jing
Wang, Xuelin
Yang, Yong
Bai, Xue
Pang, Jianda
Wang, Xinrui
Yu, Mingchuan
Liu, Mingyuan
Liu, Xiaolei
Sun, Shumin
Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection
title Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection
title_full Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection
title_fullStr Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection
title_full_unstemmed Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection
title_short Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection
title_sort regulation of host immune cells and cytokine production induced by trichinella spiralis infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921962/
https://www.ncbi.nlm.nih.gov/pubmed/31855175
http://dx.doi.org/10.1051/parasite/2019074
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