Long-Term Ibrutinib Therapy Reverses CD8(+) T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia

Chronic Lymphocytic Leukaemia (CLL) is associated with immune suppression and susceptibility to infection. CD8(+) T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function. The mechanisms driving these features of exhaustion are uncertain but are likely to includ...

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Detalles Bibliográficos
Autores principales: Parry, Helen M., Mirajkar, Nikhil, Cutmore, Natasha, Zuo, Jianmin, Long, Heather, Kwok, Marwan, Oldrieve, Ceri, Hudson, Chris, Stankovic, Tatjana, Paneesha, Shankara, Kelly, Melanie, Begum, Jusnara, McSkeane, Tina, Pratt, Guy, Moss, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921985/
https://www.ncbi.nlm.nih.gov/pubmed/31921116
http://dx.doi.org/10.3389/fimmu.2019.02832

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