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Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report
RATIONALE: Surgery for patients with multiple endocrine neoplasia type 1(MEN-1) related gastrinoma remains controversial and total pancreatectomy (TP) has rarely been performed. We reported a case of patient with MEN-1 related gastrinoma treated by TP. PATIENT CONCERNS: A 46-year-old female was admi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922403/ https://www.ncbi.nlm.nih.gov/pubmed/31852099 http://dx.doi.org/10.1097/MD.0000000000018275 |
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author | Gong, Shu Li, Zhi Liu, Xu-Bao Wang, Xin Shen, Wen-Wu |
author_facet | Gong, Shu Li, Zhi Liu, Xu-Bao Wang, Xin Shen, Wen-Wu |
author_sort | Gong, Shu |
collection | PubMed |
description | RATIONALE: Surgery for patients with multiple endocrine neoplasia type 1(MEN-1) related gastrinoma remains controversial and total pancreatectomy (TP) has rarely been performed. We reported a case of patient with MEN-1 related gastrinoma treated by TP. PATIENT CONCERNS: A 46-year-old female was admitted to our hospital due to abdominal distension and diarrhea for 2 years. The patient underwent pituitary tumor resection and kidney stone lithotripsy 10 years ago. DIAGNOSES: Abdominal computed tomography showed single lesion in the duodenum and multiple lesions throughout the pancreas. The patient's gastrin level was significantly increased (1080 pg/ml). These findings in combination with the pituitary tumor history suggested the presence of gastrinoma associated with MEN-1 syndrome. INTERVENTION: An exploratory laparotomy was performed. Intraoperative ultrasound confirmed the numerous tumors diffusely distributed throughout the pancreas and the patient eventually underwent TP. OUTCOMES: Twelve months later, the patient was hospitalized again for anastomotic fistula and underwent a partial gastrectomy, small bowel resection and drainage of the abscess. One month later, she received gastrostomy and jejunostomy due to digestive tract fistula, and died a month later (14 months after TP). LESSONS: There still might be the possibility of recurrence even after radical surgical resection of gastrinomas, and we suggest the need to measure the basal acid output and maintain regular anti-acid therapy in the long-term follow-up of patients with MEN-1 related gastrinoma. |
format | Online Article Text |
id | pubmed-6922403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-69224032020-01-23 Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report Gong, Shu Li, Zhi Liu, Xu-Bao Wang, Xin Shen, Wen-Wu Medicine (Baltimore) 7100 RATIONALE: Surgery for patients with multiple endocrine neoplasia type 1(MEN-1) related gastrinoma remains controversial and total pancreatectomy (TP) has rarely been performed. We reported a case of patient with MEN-1 related gastrinoma treated by TP. PATIENT CONCERNS: A 46-year-old female was admitted to our hospital due to abdominal distension and diarrhea for 2 years. The patient underwent pituitary tumor resection and kidney stone lithotripsy 10 years ago. DIAGNOSES: Abdominal computed tomography showed single lesion in the duodenum and multiple lesions throughout the pancreas. The patient's gastrin level was significantly increased (1080 pg/ml). These findings in combination with the pituitary tumor history suggested the presence of gastrinoma associated with MEN-1 syndrome. INTERVENTION: An exploratory laparotomy was performed. Intraoperative ultrasound confirmed the numerous tumors diffusely distributed throughout the pancreas and the patient eventually underwent TP. OUTCOMES: Twelve months later, the patient was hospitalized again for anastomotic fistula and underwent a partial gastrectomy, small bowel resection and drainage of the abscess. One month later, she received gastrostomy and jejunostomy due to digestive tract fistula, and died a month later (14 months after TP). LESSONS: There still might be the possibility of recurrence even after radical surgical resection of gastrinomas, and we suggest the need to measure the basal acid output and maintain regular anti-acid therapy in the long-term follow-up of patients with MEN-1 related gastrinoma. Wolters Kluwer Health 2019-12-16 /pmc/articles/PMC6922403/ /pubmed/31852099 http://dx.doi.org/10.1097/MD.0000000000018275 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 7100 Gong, Shu Li, Zhi Liu, Xu-Bao Wang, Xin Shen, Wen-Wu Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report |
title | Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report |
title_full | Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report |
title_fullStr | Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report |
title_full_unstemmed | Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report |
title_short | Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report |
title_sort | gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: a case report |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922403/ https://www.ncbi.nlm.nih.gov/pubmed/31852099 http://dx.doi.org/10.1097/MD.0000000000018275 |
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