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Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
BACKGROUND: Delirium's pathophysiology is poorly understood. We sought to determine if plasma biomarkers of inflammation, coagulation, endothelial activation, and blood brain barrier (BBB) injury were associated with emergency department (ED) delirium duration. METHODS: We enrolled hospitalized...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922408/ https://www.ncbi.nlm.nih.gov/pubmed/31856187 http://dx.doi.org/10.1371/journal.pone.0226412 |
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author | McNeil, J. Brennan Hughes, Christopher G. Girard, Timothy Ware, Lorraine B. Ely, E. Wesley Chandrasekhar, Rameela Han, Jin H. |
author_facet | McNeil, J. Brennan Hughes, Christopher G. Girard, Timothy Ware, Lorraine B. Ely, E. Wesley Chandrasekhar, Rameela Han, Jin H. |
author_sort | McNeil, J. Brennan |
collection | PubMed |
description | BACKGROUND: Delirium's pathophysiology is poorly understood. We sought to determine if plasma biomarkers of inflammation, coagulation, endothelial activation, and blood brain barrier (BBB) injury were associated with emergency department (ED) delirium duration. METHODS: We enrolled hospitalized patients who were 65 years or older from the ED. Plasma biomarkers of inflammation (interleukin-6 [IL-6], IL-8, soluble tumor necrosis factor receptor I [sTNFRI]), coagulation (Protein C), endothelial activation (plasminogen activating inhibitor-1 [PAI-1]), and BBB injury (S100B) at were measured using blood obtained at enrollment. The dependent variable was ED delirium duration which was determined by the Brief Confusion Assessment Method assessed in the ED and hospitalization. Proportional odds logistic regression analyses were performed adjusted for relevant confounders and allowing for interaction by baseline dementia status. RESULTS: A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32) and PAI-1 (POR = 2.96, 95%CI: 1.48 to 6.85) were independently associated with more prominent ED delirium duration in subjects without dementia only. No significant associations between IL-8, Protein C, sTNRFI, and S100B and ED delirium duration were observed. CONCLUSIONS: Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. |
format | Online Article Text |
id | pubmed-6922408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69224082020-01-07 Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients McNeil, J. Brennan Hughes, Christopher G. Girard, Timothy Ware, Lorraine B. Ely, E. Wesley Chandrasekhar, Rameela Han, Jin H. PLoS One Research Article BACKGROUND: Delirium's pathophysiology is poorly understood. We sought to determine if plasma biomarkers of inflammation, coagulation, endothelial activation, and blood brain barrier (BBB) injury were associated with emergency department (ED) delirium duration. METHODS: We enrolled hospitalized patients who were 65 years or older from the ED. Plasma biomarkers of inflammation (interleukin-6 [IL-6], IL-8, soluble tumor necrosis factor receptor I [sTNFRI]), coagulation (Protein C), endothelial activation (plasminogen activating inhibitor-1 [PAI-1]), and BBB injury (S100B) at were measured using blood obtained at enrollment. The dependent variable was ED delirium duration which was determined by the Brief Confusion Assessment Method assessed in the ED and hospitalization. Proportional odds logistic regression analyses were performed adjusted for relevant confounders and allowing for interaction by baseline dementia status. RESULTS: A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32) and PAI-1 (POR = 2.96, 95%CI: 1.48 to 6.85) were independently associated with more prominent ED delirium duration in subjects without dementia only. No significant associations between IL-8, Protein C, sTNRFI, and S100B and ED delirium duration were observed. CONCLUSIONS: Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. Public Library of Science 2019-12-19 /pmc/articles/PMC6922408/ /pubmed/31856187 http://dx.doi.org/10.1371/journal.pone.0226412 Text en © 2019 McNeil et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article McNeil, J. Brennan Hughes, Christopher G. Girard, Timothy Ware, Lorraine B. Ely, E. Wesley Chandrasekhar, Rameela Han, Jin H. Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
title | Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
title_full | Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
title_fullStr | Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
title_full_unstemmed | Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
title_short | Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
title_sort | plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922408/ https://www.ncbi.nlm.nih.gov/pubmed/31856187 http://dx.doi.org/10.1371/journal.pone.0226412 |
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