Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

Prion or PrP(Sc) is the proteinaceous infectious agent causing prion diseases in various mammalian species. Despite decades of research, the structural basis for PrP(Sc) formation and prion infectivity remains elusive. To understand the role of the hydrophobic region in forming infectious prion at t...

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Detalles Bibliográficos
Autores principales: Abskharon, Romany, Wang, Fei, Wohlkonig, Alexandre, Ruan, Juxin, Soror, Sameh, Giachin, Gabriele, Pardon, Els, Zou, Wenquan, Legname, Giuseppe, Ma, Jiyan, Steyaert, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922452/
https://www.ncbi.nlm.nih.gov/pubmed/31815959
http://dx.doi.org/10.1371/journal.ppat.1008139

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