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Harnessing biocompatible chemistry for developing improved and novel microbial cell factories
White biotechnology relies on the sophisticated chemical machinery inside living cells for producing a broad range of useful compounds in a sustainable and environmentally friendly way. However, despite the impressive repertoire of compounds that can be generated using white biotechnology, this appr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922530/ https://www.ncbi.nlm.nih.gov/pubmed/31386283 http://dx.doi.org/10.1111/1751-7915.13472 |
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author | Liu, Jian‐Ming Solem, Christian Jensen, Peter Ruhdal |
author_facet | Liu, Jian‐Ming Solem, Christian Jensen, Peter Ruhdal |
author_sort | Liu, Jian‐Ming |
collection | PubMed |
description | White biotechnology relies on the sophisticated chemical machinery inside living cells for producing a broad range of useful compounds in a sustainable and environmentally friendly way. However, despite the impressive repertoire of compounds that can be generated using white biotechnology, this approach cannot currently fully replace traditional chemical production, often relying on petroleum as a raw material. One challenge is the limited number of chemical transformations taking place in living organisms. Biocompatible chemistry, that is non‐enzymatic chemical reactions taking place under mild conditions compatible with living organisms, could provide a solution. Biocompatible chemistry is not a novel invention, and has since long been used by living organisms. Examples include Fenton chemistry, used by microorganisms for degrading plant materials, and manganese or ketoacids dependent chemistry used for detoxifying reactive oxygen species. However, harnessing biocompatible chemistry for expanding the chemical repertoire of living cells is a relatively novel approach within white biotechnology, and it could potentially be used for producing valuable compounds which living organisms otherwise are not able to generate. In this mini review, we discuss such applications of biocompatible chemistry, and clarify the potential that lies in using biocompatible chemistry in conjunction with metabolically engineered cell factories for cheap substrate utilization, improved cell physiology, efficient pathway construction and novel chemicals production. |
format | Online Article Text |
id | pubmed-6922530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69225302019-12-30 Harnessing biocompatible chemistry for developing improved and novel microbial cell factories Liu, Jian‐Ming Solem, Christian Jensen, Peter Ruhdal Microb Biotechnol Minireviews White biotechnology relies on the sophisticated chemical machinery inside living cells for producing a broad range of useful compounds in a sustainable and environmentally friendly way. However, despite the impressive repertoire of compounds that can be generated using white biotechnology, this approach cannot currently fully replace traditional chemical production, often relying on petroleum as a raw material. One challenge is the limited number of chemical transformations taking place in living organisms. Biocompatible chemistry, that is non‐enzymatic chemical reactions taking place under mild conditions compatible with living organisms, could provide a solution. Biocompatible chemistry is not a novel invention, and has since long been used by living organisms. Examples include Fenton chemistry, used by microorganisms for degrading plant materials, and manganese or ketoacids dependent chemistry used for detoxifying reactive oxygen species. However, harnessing biocompatible chemistry for expanding the chemical repertoire of living cells is a relatively novel approach within white biotechnology, and it could potentially be used for producing valuable compounds which living organisms otherwise are not able to generate. In this mini review, we discuss such applications of biocompatible chemistry, and clarify the potential that lies in using biocompatible chemistry in conjunction with metabolically engineered cell factories for cheap substrate utilization, improved cell physiology, efficient pathway construction and novel chemicals production. John Wiley and Sons Inc. 2019-08-06 /pmc/articles/PMC6922530/ /pubmed/31386283 http://dx.doi.org/10.1111/1751-7915.13472 Text en © 2019 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireviews Liu, Jian‐Ming Solem, Christian Jensen, Peter Ruhdal Harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
title | Harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
title_full | Harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
title_fullStr | Harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
title_full_unstemmed | Harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
title_short | Harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
title_sort | harnessing biocompatible chemistry for developing improved and novel microbial cell factories |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922530/ https://www.ncbi.nlm.nih.gov/pubmed/31386283 http://dx.doi.org/10.1111/1751-7915.13472 |
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