Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

The endoplasmic reticulum (ER) is responsible for folding secretory and membrane proteins, but disturbed ER proteostasis may lead to protein aggregation and subsequent cellular and clinical pathologies. Chemical chaperones have recently emerged as a potential therapeutic approach for ER stress-relat...

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Detalles Bibliográficos
Autores principales: Kitakaze, Keisuke, Taniuchi, Shusuke, Kawano, Eri, Hamada, Yoshimasa, Miyake, Masato, Oyadomari, Miho, Kojima, Hirotatsu, Kosako, Hidetaka, Kuribara, Tomoko, Yoshida, Suguru, Hosoya, Takamitsu, Oyadomari, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922633/
https://www.ncbi.nlm.nih.gov/pubmed/31843052
http://dx.doi.org/10.7554/eLife.43302

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