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Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion

Background: The prognosis is poor for patients with symptomatic subacute to chronic atherosclerotic basilar artery occlusion (BAO) refractory to medical therapy. There has been no consensus on the optimal treatment for these patients until now. Objectives: To assess the feasibility of endovascular r...

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Autores principales: Zhao, Wei, Zhang, Jinping, Song, Yun, Sun, Lili, Zheng, Meimei, Yin, Hao, Zhang, Jun, Wang, Wei, Han, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923246/
https://www.ncbi.nlm.nih.gov/pubmed/31920916
http://dx.doi.org/10.3389/fneur.2019.01290
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author Zhao, Wei
Zhang, Jinping
Song, Yun
Sun, Lili
Zheng, Meimei
Yin, Hao
Zhang, Jun
Wang, Wei
Han, Ju
author_facet Zhao, Wei
Zhang, Jinping
Song, Yun
Sun, Lili
Zheng, Meimei
Yin, Hao
Zhang, Jun
Wang, Wei
Han, Ju
author_sort Zhao, Wei
collection PubMed
description Background: The prognosis is poor for patients with symptomatic subacute to chronic atherosclerotic basilar artery occlusion (BAO) refractory to medical therapy. There has been no consensus on the optimal treatment for these patients until now. Objectives: To assess the feasibility of endovascular recanalization for patients with symptomatic subacute to chronic atherosclerotic BAO refractory to medical therapy. Methods: Consecutive patients who underwent endovascular recanalization for symptomatic subacute to chronic symptomatic atherosclerotic BAO from May 2015 to October 2018 were enrolled in our stroke center. Demographic, clinical, angiographic, procedural, and follow-up data were collected and analyzed. Results: Twenty-one patients were enrolled in this study [mean age 57.9 years; 90.5% male; median pretreatment National Institutes of Health Stroke Scale (NIHSS) score 10; median time from image-documented BAO to treatment 15 days]. The success rate of the procedure was 81.0% (17/21). Periprocedural perforator strokes occurred in two patients (9.5%, 2/21). At 90 days, there was one death due to pneumonia (unrelated to the procedure), and there were no recurrent cases of TIA or stroke in the other 16 patients. At 90 days, 76.5% (13/17) of patients achieved a good clinical outcome [mRS: modified Rankin Scale (mRS) scores 0–2], and 94.1% (16/17) of patients achieved an acceptable outcome (mRS scores 0–3). During the 17.4 ± 8.0-month clinical follow-up period, one patient suffered from Wallenberg syndrome at 29 months. Conclusions: Our study suggests that endovascular recanalization for subacute to chronic symptomatic atherosclerotic BAO appears to be feasible in selected patients.
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spelling pubmed-69232462020-01-09 Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion Zhao, Wei Zhang, Jinping Song, Yun Sun, Lili Zheng, Meimei Yin, Hao Zhang, Jun Wang, Wei Han, Ju Front Neurol Neurology Background: The prognosis is poor for patients with symptomatic subacute to chronic atherosclerotic basilar artery occlusion (BAO) refractory to medical therapy. There has been no consensus on the optimal treatment for these patients until now. Objectives: To assess the feasibility of endovascular recanalization for patients with symptomatic subacute to chronic atherosclerotic BAO refractory to medical therapy. Methods: Consecutive patients who underwent endovascular recanalization for symptomatic subacute to chronic symptomatic atherosclerotic BAO from May 2015 to October 2018 were enrolled in our stroke center. Demographic, clinical, angiographic, procedural, and follow-up data were collected and analyzed. Results: Twenty-one patients were enrolled in this study [mean age 57.9 years; 90.5% male; median pretreatment National Institutes of Health Stroke Scale (NIHSS) score 10; median time from image-documented BAO to treatment 15 days]. The success rate of the procedure was 81.0% (17/21). Periprocedural perforator strokes occurred in two patients (9.5%, 2/21). At 90 days, there was one death due to pneumonia (unrelated to the procedure), and there were no recurrent cases of TIA or stroke in the other 16 patients. At 90 days, 76.5% (13/17) of patients achieved a good clinical outcome [mRS: modified Rankin Scale (mRS) scores 0–2], and 94.1% (16/17) of patients achieved an acceptable outcome (mRS scores 0–3). During the 17.4 ± 8.0-month clinical follow-up period, one patient suffered from Wallenberg syndrome at 29 months. Conclusions: Our study suggests that endovascular recanalization for subacute to chronic symptomatic atherosclerotic BAO appears to be feasible in selected patients. Frontiers Media S.A. 2019-12-13 /pmc/articles/PMC6923246/ /pubmed/31920916 http://dx.doi.org/10.3389/fneur.2019.01290 Text en Copyright © 2019 Zhao, Zhang, Song, Sun, Zheng, Yin, Zhang, Wang and Han. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhao, Wei
Zhang, Jinping
Song, Yun
Sun, Lili
Zheng, Meimei
Yin, Hao
Zhang, Jun
Wang, Wei
Han, Ju
Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion
title Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion
title_full Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion
title_fullStr Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion
title_full_unstemmed Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion
title_short Endovascular Recanalization for Symptomatic Subacute to Chronic Atherosclerotic Basilar Artery Occlusion
title_sort endovascular recanalization for symptomatic subacute to chronic atherosclerotic basilar artery occlusion
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923246/
https://www.ncbi.nlm.nih.gov/pubmed/31920916
http://dx.doi.org/10.3389/fneur.2019.01290
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