Cargando…

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges

Polygonum multiflorum Thunb. (PM), called Heshouwu in China, is a popular Chinese medicine in clinical practice. Several clinical studies have been conducted to evaluate the traditional therapeutic claims and to study the potential therapeutic activity of PM in dyslipidemia and neurodegenerative dis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yi, Wang, Wenping, Sun, Mingyi, Ma, Baorui, Pang, Linnuo, Du, Yuanyuan, Dong, Xiaoxv, Yin, Xingbin, Ni, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923272/ https://www.ncbi.nlm.nih.gov/pubmed/31920657 http://dx.doi.org/10.3389/fphar.2019.01467

Ejemplares similares

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
por: You, Longtai, et al.
Publicado: (2020)

A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor
por: Lin, Longfei, et al.
Publicado: (2017)

Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches
por: Li, Yun-Xia, et al.
Publicado: (2017)

Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study
por: Dong, Qin, et al.
Publicado: (2015)

Changes of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides During Processing of Polygonum multiflorum Thunb
por: Gu, Donglin, et al.
Publicado: (2022)

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review
por: Lin, Longfei, et al.
Publicado: (2015)

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
por: Zhang, Miao, et al.
Publicado: (2018)

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
por: Liu, Yue, et al.
Publicado: (2018)

Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats
por: Tu, Can, et al.
Publicado: (2019)

Germplasm preservation in vitro of Polygonum multiflorum Thunb
por: Huang, He-Ping, et al.
Publicado: (2014)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
por: Han, Lifeng, et al.
Publicado: (2019)

Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models
por: Ma, Ninghui, et al.
Publicado: (2021)

A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum
por: Song, Yunfei, et al.
Publicado: (2022)

Effects of Different Processed Products of Polygonum multiflorum on the Liver
por: Li, Ruo-Lan, et al.
Publicado: (2020)

New phenolic constituents obtained from Polygonum multiflorum
por: Yang, Jian-bo, et al.
Publicado: (2020)

Metabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched Pathways Analysis
por: Li, Chun-Yu, et al.
Publicado: (2016)

Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum
por: Li, Yunfei, et al.
Publicado: (2015)

Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying
por: Han, Ming-Nuan, et al.
Publicado: (2015)

Preventive effects of Polygonum multiflorum on glucocorticoid-induced osteoporosis in rats
por: Zhou, Manru, et al.
Publicado: (2017)

Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum
por: Yu, He-Shui, et al.
Publicado: (2020)

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds
por: Bounda, Guy-Armel, et al.
Publicado: (2015)

Characterization of Proanthocyanidins in Stems of Polygonum multiflorum Thunb as Strong Starch Hydrolase Inhibitors
por: Wang, Hongyu, et al.
Publicado: (2013)

Heshouwu (Polygonum multiflorum Thunb.) Extract Attenuates Bone Loss in Diabetic Mice
por: Ham, Ju Ri, et al.
Publicado: (2019)

Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans
por: Tu, Can, et al.
Publicado: (2021)

Diagnosis and Management of Drug-Induced Liver Injury After the Use of Polygonum multiflorum
por: Zahir, Ali, et al.
Publicado: (2022)

Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum: A case report
por: Shao, You-Lin, et al.
Publicado: (2022)

Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population
por: Yang, Wan-Na, et al.
Publicado: (2020)

Polygonum multiflorum root extract as a potential candidate for treatment of early graying hair
por: Thang, Nguyen Dinh, et al.
Publicado: (2017)

Effects of Hot Water Extracts from Polygonum multiflorum on Ovariectomy Induced Osteopenia in Mice
por: Hwang, Yun-Ho, et al.
Publicado: (2016)

Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS
por: Lin, Yan, et al.
Publicado: (2021)

A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb.
por: Li, Yun-xia, et al.
Publicado: (2017)

Enhanced Production of Anthraquinones and Phenolic Compounds and Biological Activities in the Cell Suspension Cultures of Polygonum multiflorum
por: Thiruvengadam, Muthu, et al.
Publicado: (2016)

Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity
por: Zheng, Yayuan, et al.
Publicado: (2017)

Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum
por: Zhang, Lingling, et al.
Publicado: (2018)

Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology
por: Song, Yunfei, et al.
Publicado: (2020)

Discovery of Hepatotoxic Equivalent Markers and Mechanism of Polygonum multiflorum Thunb. by Metabolomics Coupled with Molecular Docking
por: Zhang, Yinhuan, et al.
Publicado: (2022)

Exploratory Quality Control Study for Polygonum multiflorum Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity
por: Gao, Huiyu, et al.
Publicado: (2022)

Deep sequencing reveals transcriptome re-programming of Polygonum multiflorum thunb. roots to the elicitation with methyl jasmonate
por: Liu, Hongchang, et al.
Publicado: (2015)

Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
por: Lei, Xiang, et al.
Publicado: (2015)

Application of microscopy technique and high performance liquid chromatography for quality assessment of Polygonum multiflorum Thunb. (Heshouwu)
por: Liang, Li, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_uko0d3grkf9b4u763oeq84dhq6