The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment

The multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the other ILC family members can either promote or inhibit tumor growth dependi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ducimetière, Laura, Vermeer, Marijne, Tugues, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923277/
https://www.ncbi.nlm.nih.gov/pubmed/31921156
http://dx.doi.org/10.3389/fimmu.2019.02895
_version_ 1783481499454013440
author Ducimetière, Laura
Vermeer, Marijne
Tugues, Sonia
author_facet Ducimetière, Laura
Vermeer, Marijne
Tugues, Sonia
author_sort Ducimetière, Laura
collection PubMed
description The multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the other ILC family members can either promote or inhibit tumor growth depending on the environmental conditions. The differential effects of ILCs on tumor outcome have been attributed to the high degree of heterogeneity and plasticity within the ILC family members. However, it is now becoming clear that ILCs responses are shaped by their dynamic crosstalk with the different components of the tumor microenvironment (TME). In this review, we will give insights into the molecular and cellular players of the ILCs-TME interactions and we will discuss how we can use this knowledge to successfully harness the activity of ILCs for anticancer therapies.
format Online
Article
Text
id pubmed-6923277
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69232772020-01-09 The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment Ducimetière, Laura Vermeer, Marijne Tugues, Sonia Front Immunol Immunology The multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the other ILC family members can either promote or inhibit tumor growth depending on the environmental conditions. The differential effects of ILCs on tumor outcome have been attributed to the high degree of heterogeneity and plasticity within the ILC family members. However, it is now becoming clear that ILCs responses are shaped by their dynamic crosstalk with the different components of the tumor microenvironment (TME). In this review, we will give insights into the molecular and cellular players of the ILCs-TME interactions and we will discuss how we can use this knowledge to successfully harness the activity of ILCs for anticancer therapies. Frontiers Media S.A. 2019-12-13 /pmc/articles/PMC6923277/ /pubmed/31921156 http://dx.doi.org/10.3389/fimmu.2019.02895 Text en Copyright © 2019 Ducimetière, Vermeer and Tugues. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ducimetière, Laura
Vermeer, Marijne
Tugues, Sonia
The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
title The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
title_full The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
title_fullStr The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
title_full_unstemmed The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
title_short The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment
title_sort interplay between innate lymphoid cells and the tumor microenvironment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923277/
https://www.ncbi.nlm.nih.gov/pubmed/31921156
http://dx.doi.org/10.3389/fimmu.2019.02895
work_keys_str_mv AT ducimetierelaura theinterplaybetweeninnatelymphoidcellsandthetumormicroenvironment
AT vermeermarijne theinterplaybetweeninnatelymphoidcellsandthetumormicroenvironment
AT tuguessonia theinterplaybetweeninnatelymphoidcellsandthetumormicroenvironment
AT ducimetierelaura interplaybetweeninnatelymphoidcellsandthetumormicroenvironment
AT vermeermarijne interplaybetweeninnatelymphoidcellsandthetumormicroenvironment
AT tuguessonia interplaybetweeninnatelymphoidcellsandthetumormicroenvironment

Ejemplares similares