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Construction of rat spinal cord injury model based on Allen’s animal model
The aim of this study is to explore the construction of rat spinal cord injury model guided by Allen's model. Methods: Male rats aged 4–5 weeks and weighing about 250 g are selected as subjects in the Animal Laboratory Center of XX Hospital. Rats are divided into two groups, which are experimen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923460/ https://www.ncbi.nlm.nih.gov/pubmed/31889806 http://dx.doi.org/10.1016/j.sjbs.2019.09.033 |
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author | Li, Shuliang Zhou, Jiangbo Zhang, Jianjun Wang, Dong Ma, Jingjian |
author_facet | Li, Shuliang Zhou, Jiangbo Zhang, Jianjun Wang, Dong Ma, Jingjian |
author_sort | Li, Shuliang |
collection | PubMed |
description | The aim of this study is to explore the construction of rat spinal cord injury model guided by Allen's model. Methods: Male rats aged 4–5 weeks and weighing about 250 g are selected as subjects in the Animal Laboratory Center of XX Hospital. Rats are divided into two groups, which are experimental group 1 and experimental group 2, respectively, so as to construct spinal cord injury model in rats. The first group is given 300 g.cm hitting force of T10 spinal cord, and the second group is given 500 g.cm hitting force of T10 spinal cord. Within 25 days after spinal cord injury in Allen's rats, the survival, neurological function, diet, motor ability, tactile ability and auditory ability of the two groups are monitored and evaluated daily. Results: In terms of survival, the survival rate of rats in group 1 is 85%, while that of rats in group 2 is 21%, and there is a concentrated death phenomenon in group 2. In terms of neurological function recovery, experimental group 1 is stable and gets 7 points and experimental group 2 is stable and gets 3 points. In terms of diet, the experimental group 1 is stable and gets 5 points and the experimental group 2 is stable and gets 2 points. In terms of motor ability, the experimental group 1 is stable and gets 5 points and the experimental group 2 is stable and gets 2 points. In tactile sense, experimental group 1 is stable and gets 17 points and experimental group 2 is stable and gets 12 points. It can be seen that the post-operative recovery ability of the experimental group 1 is better than that of the experimental group 2. Conclusion: Under the guidance of Allen's model, compared with the group 2, the experimental group 1 of the rat spinal cord injury model has better recovery in each index. It can be seen that the smaller impact strength is more beneficial to the recovery of rats after spinal cord injury surgery. |
format | Online Article Text |
id | pubmed-6923460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69234602019-12-30 Construction of rat spinal cord injury model based on Allen’s animal model Li, Shuliang Zhou, Jiangbo Zhang, Jianjun Wang, Dong Ma, Jingjian Saudi J Biol Sci Article The aim of this study is to explore the construction of rat spinal cord injury model guided by Allen's model. Methods: Male rats aged 4–5 weeks and weighing about 250 g are selected as subjects in the Animal Laboratory Center of XX Hospital. Rats are divided into two groups, which are experimental group 1 and experimental group 2, respectively, so as to construct spinal cord injury model in rats. The first group is given 300 g.cm hitting force of T10 spinal cord, and the second group is given 500 g.cm hitting force of T10 spinal cord. Within 25 days after spinal cord injury in Allen's rats, the survival, neurological function, diet, motor ability, tactile ability and auditory ability of the two groups are monitored and evaluated daily. Results: In terms of survival, the survival rate of rats in group 1 is 85%, while that of rats in group 2 is 21%, and there is a concentrated death phenomenon in group 2. In terms of neurological function recovery, experimental group 1 is stable and gets 7 points and experimental group 2 is stable and gets 3 points. In terms of diet, the experimental group 1 is stable and gets 5 points and the experimental group 2 is stable and gets 2 points. In terms of motor ability, the experimental group 1 is stable and gets 5 points and the experimental group 2 is stable and gets 2 points. In tactile sense, experimental group 1 is stable and gets 17 points and experimental group 2 is stable and gets 12 points. It can be seen that the post-operative recovery ability of the experimental group 1 is better than that of the experimental group 2. Conclusion: Under the guidance of Allen's model, compared with the group 2, the experimental group 1 of the rat spinal cord injury model has better recovery in each index. It can be seen that the smaller impact strength is more beneficial to the recovery of rats after spinal cord injury surgery. Elsevier 2019-12 2019-10-16 /pmc/articles/PMC6923460/ /pubmed/31889806 http://dx.doi.org/10.1016/j.sjbs.2019.09.033 Text en © 2019 Published by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Li, Shuliang Zhou, Jiangbo Zhang, Jianjun Wang, Dong Ma, Jingjian Construction of rat spinal cord injury model based on Allen’s animal model |
title | Construction of rat spinal cord injury model based on Allen’s animal model |
title_full | Construction of rat spinal cord injury model based on Allen’s animal model |
title_fullStr | Construction of rat spinal cord injury model based on Allen’s animal model |
title_full_unstemmed | Construction of rat spinal cord injury model based on Allen’s animal model |
title_short | Construction of rat spinal cord injury model based on Allen’s animal model |
title_sort | construction of rat spinal cord injury model based on allen’s animal model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923460/ https://www.ncbi.nlm.nih.gov/pubmed/31889806 http://dx.doi.org/10.1016/j.sjbs.2019.09.033 |
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