Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block

Although the tricyclic antidepressant amitriptyline (ATL) is widely used in the clinic, the mechanism underlying its high therapeutic efficacy against neuropathic pain remains unclear. NMDA receptors (NMDARs) represent a target for ATL and are involved in sensitization of neuropathic pain. Here we d...

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Detalles Bibliográficos
Autores principales: Stepanenko, Yulia D., Boikov, Sergei I., Sibarov, Dmitry A., Abushik, Polina A., Vanchakova, Nina P., Belinskaia, Daria, Shestakova, Natalia N., Antonov, Sergei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923474/
https://www.ncbi.nlm.nih.gov/pubmed/31857688
http://dx.doi.org/10.1038/s41598-019-56072-z

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