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Combined gene essentiality scoring improves the prediction of cancer dependency maps

BACKGROUND: Probing genetic dependencies of cancer cells can improve our understanding of tumour development and progression, as well as identify potential drug targets. CRISPR-Cas9-based and shRNA-based genetic screening are commonly utilized to identify essential genes that affect cancer growth. H...

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Detalles Bibliográficos
Autores principales:	Wang, Wenyu, Malyutina, Alina, Pessia, Alberto, Saarela, Jani, Heckman, Caroline A., Tang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923492/ https://www.ncbi.nlm.nih.gov/pubmed/31732481 http://dx.doi.org/10.1016/j.ebiom.2019.10.051

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