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Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses

We describe a strategy to achieve footprintless bi-allelic homology-directed repair (HDR) using helper-dependent adenoviruses (HDAds). This approach utilizes two HDAds to deliver the donor DNA. These two HDAds are identical except for their selectable marker. One expresses the puromycin N-acetyltran...

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Detalles Bibliográficos
Autores principales:	Palmer, Donna J., Turner, Dustin L., Ng, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923503/ https://www.ncbi.nlm.nih.gov/pubmed/31890728 http://dx.doi.org/10.1016/j.omtm.2019.10.003

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