Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin 1 receptor (IL-1R)-dependent caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6(ΔPMN)) is sufficient to initiate IL-1R-dependent cutaneous inflammatory disease, but th...

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Detalles Bibliográficos
Autores principales: Speir, Mary, Nowell, Cameron J., Chen, Alyce A., O’Donnell, Joanne A., Shamie, Isaac S., Lakin, Paul R., D’Cruz, Akshay A., Braun, Roman O., Babon, Jeff J., Lewis, Rowena S., Bliss-Moreau, Meghan, Shlomovitz, Inbar, Wang, Shu, Cengia, Louise H., Stoica, Anca I., Hakem, Razq, Kelliher, Michelle A., O’Reilly, Lorraine A., Patsiouras, Heather, Lawlor, Kate E, Weller, Edie, Lewis, Nathan E., Roberts, Andrew W., Gerlic, Motti, Croker, Ben A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923591/
https://www.ncbi.nlm.nih.gov/pubmed/31819256
http://dx.doi.org/10.1038/s41590-019-0550-7

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