KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

BACKGROUND: Ketamine, a widely used anaesthetic and analgesic agent, is known to improve the analgesic efficacy of opioids and to attenuate central sensitisation and opioid-induced hyperalgesia. Clinical use is, however, curtailed by unwanted psychomimetic effects thought to be mediated by N-methyl-...

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Detalles Bibliográficos
Autores principales: Harvey, Martyn, Sleigh, Jamie, Voss, Logan, Bickerdike, Mike, Dimitrov, Ivaylo, Denny, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923863/
https://www.ncbi.nlm.nih.gov/pubmed/31856925
http://dx.doi.org/10.1186/s40360-019-0374-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923863/
https://www.ncbi.nlm.nih.gov/pubmed/31856925
http://dx.doi.org/10.1186/s40360-019-0374-y

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