Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a factor up-regulated by astrocytes in active inflammatory lesions that disrupts myelination...

Descripción completa

Detalles Bibliográficos
Autores principales: Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John J., Arseni, Diana, Mücklisch, Steve, Edgar, Julia M., Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923900/
https://www.ncbi.nlm.nih.gov/pubmed/31856924
http://dx.doi.org/10.1186/s40478-019-0864-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923900/
https://www.ncbi.nlm.nih.gov/pubmed/31856924
http://dx.doi.org/10.1186/s40478-019-0864-6

Ejemplares similares