Pharmacodynamics of Pre-Operative PD1 checkpoint blockade and receptor activator of NFkB ligand (RANKL) inhibition in non-small cell lung cancer (NSCLC): study protocol for a multicentre, open-label, phase 1B/2, translational trial (POPCORN)

BACKGROUND: Neoadjuvant immunotherapy targeting immune checkpoint programmed death-1 (PD-1) is under investigation in various tumour settings including non-small-cell lung cancer (NSCLC). Preclinical models demonstrate the superior power of the immunotherapy provided in a neoadjuvant (pre-operative)...

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Detalles Bibliográficos
Autores principales: Ahern, Elizabeth, Cubitt, Annette, Ballard, Emma, Teng, Michele W. L., Dougall, William C., Smyth, Mark J., Godbolt, David, Naidoo, Rishendran, Goldrick, Amanda, Hughes, Brett G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924018/
https://www.ncbi.nlm.nih.gov/pubmed/31856909
http://dx.doi.org/10.1186/s13063-019-3951-x

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