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RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery

BACKGROUND: Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have advantages over fresh frozen tissue including abundance and availability, connection to rich clinical data, and association with patient outcomes. However, FFPE-derived RNA is highly degraded and chemically modified, which...

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Detalles Bibliográficos
Autores principales:	Pennock, Nathan D., Jindal, Sonali, Horton, Wesley, Sun, Duanchen, Narasimhan, Jayasri, Carbone, Lucia, Fei, Suzanne S., Searles, Robert, Harrington, Christina A., Burchard, Julja, Weinmann, Sheila, Schedin, Pepper, Xia, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924022/ https://www.ncbi.nlm.nih.gov/pubmed/31856832 http://dx.doi.org/10.1186/s12920-019-0643-z

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