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Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation of endogenous α-synuclein aggregates...

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Detalles Bibliográficos
Autores principales:	Elfarrash, Sara, Jensen, Nanna Møller, Ferreira, Nelson, Betzer, Cristine, Thevathasan, Jervis Vermal, Diekmann, Robin, Adel, Mohamed, Omar, Nisreen Mansour, Boraie, Mohamed Z., Gad, Sabry, Ries, Jonas, Kirik, Deniz, Nabavi, Sadegh, Jensen, Poul Henning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924077/ https://www.ncbi.nlm.nih.gov/pubmed/31856920 http://dx.doi.org/10.1186/s40478-019-0865-5

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