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Significant function and research progress of biomarkers in gastric cancer

Gastric cancer is one of the most common gastrointestinal tumor types, and the incidence and mortality rates are higher in men compared with women. Various studies have revealed that gastric cancer is a spectrum of tumor types, which have biological and genetic diversity. It has proven to be difficu...

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Autores principales: Ye, Dong Mei, Xu, Gaosheng, Ma, Wei, Li, Yuxuan, Luo, Weiru, Xiao, Yiyang, Liu, Yong, Zhang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924079/
https://www.ncbi.nlm.nih.gov/pubmed/31897111
http://dx.doi.org/10.3892/ol.2019.11078
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author Ye, Dong Mei
Xu, Gaosheng
Ma, Wei
Li, Yuxuan
Luo, Weiru
Xiao, Yiyang
Liu, Yong
Zhang, Zhiwei
author_facet Ye, Dong Mei
Xu, Gaosheng
Ma, Wei
Li, Yuxuan
Luo, Weiru
Xiao, Yiyang
Liu, Yong
Zhang, Zhiwei
author_sort Ye, Dong Mei
collection PubMed
description Gastric cancer is one of the most common gastrointestinal tumor types, and the incidence and mortality rates are higher in men compared with women. Various studies have revealed that gastric cancer is a spectrum of tumor types, which have biological and genetic diversity. It has proven to be difficult to improve the overall survival and disease-free survival of patients with gastric cancer through the use of traditional surgery and chemoradiation, as gastric cancer is usually identified at an advanced stage. In consequence, the outcome is frequently poor. Thus, novel biomarkers and anticancer targets are required to improve the outcome. As the identification of biomarkers has increased due to advances in research and the greater availability of bioinformatics and functional genomics, the potential therapeutic regimens available have also increased concurrently. These advances have also improved the ability to predict responses to chemotherapy, targeted therapy and immunotherapy, whilst other biomarkers predict post-treatment survival and recurrence based on their expression. This review focuses closely on the important functions of biomarkers in the timely diagnosis and treatment of gastric cancer, in addition to the advances in the study of certain novel markers in gastric cancer.
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spelling pubmed-69240792020-01-02 Significant function and research progress of biomarkers in gastric cancer Ye, Dong Mei Xu, Gaosheng Ma, Wei Li, Yuxuan Luo, Weiru Xiao, Yiyang Liu, Yong Zhang, Zhiwei Oncol Lett Review Gastric cancer is one of the most common gastrointestinal tumor types, and the incidence and mortality rates are higher in men compared with women. Various studies have revealed that gastric cancer is a spectrum of tumor types, which have biological and genetic diversity. It has proven to be difficult to improve the overall survival and disease-free survival of patients with gastric cancer through the use of traditional surgery and chemoradiation, as gastric cancer is usually identified at an advanced stage. In consequence, the outcome is frequently poor. Thus, novel biomarkers and anticancer targets are required to improve the outcome. As the identification of biomarkers has increased due to advances in research and the greater availability of bioinformatics and functional genomics, the potential therapeutic regimens available have also increased concurrently. These advances have also improved the ability to predict responses to chemotherapy, targeted therapy and immunotherapy, whilst other biomarkers predict post-treatment survival and recurrence based on their expression. This review focuses closely on the important functions of biomarkers in the timely diagnosis and treatment of gastric cancer, in addition to the advances in the study of certain novel markers in gastric cancer. D.A. Spandidos 2020-01 2019-11-11 /pmc/articles/PMC6924079/ /pubmed/31897111 http://dx.doi.org/10.3892/ol.2019.11078 Text en Copyright: © Ye et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Ye, Dong Mei
Xu, Gaosheng
Ma, Wei
Li, Yuxuan
Luo, Weiru
Xiao, Yiyang
Liu, Yong
Zhang, Zhiwei
Significant function and research progress of biomarkers in gastric cancer
title Significant function and research progress of biomarkers in gastric cancer
title_full Significant function and research progress of biomarkers in gastric cancer
title_fullStr Significant function and research progress of biomarkers in gastric cancer
title_full_unstemmed Significant function and research progress of biomarkers in gastric cancer
title_short Significant function and research progress of biomarkers in gastric cancer
title_sort significant function and research progress of biomarkers in gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924079/
https://www.ncbi.nlm.nih.gov/pubmed/31897111
http://dx.doi.org/10.3892/ol.2019.11078
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