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Expression and function of long non-coding RNA LINC01420 in thyroid cancer

The Human Genome Project revealed that >90% of the human genome was found to transcribe non-coding RNAs, including micro RNAs and long non-coding RNAs (lncRNAs). lncRNAs have been identified to play a crucial role in cancer progression. Thyroid cancer (TC) is a common type of endocrine cancer; ho...

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Autores principales: Luo, Jin-Zhu, Qin, Lu, Zhang, Ling-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924109/
https://www.ncbi.nlm.nih.gov/pubmed/31897152
http://dx.doi.org/10.3892/ol.2019.11076
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author Luo, Jin-Zhu
Qin, Lu
Zhang, Ling-Jie
author_facet Luo, Jin-Zhu
Qin, Lu
Zhang, Ling-Jie
author_sort Luo, Jin-Zhu
collection PubMed
description The Human Genome Project revealed that >90% of the human genome was found to transcribe non-coding RNAs, including micro RNAs and long non-coding RNAs (lncRNAs). lncRNAs have been identified to play a crucial role in cancer progression. Thyroid cancer (TC) is a common type of endocrine cancer; however, the functional roles of lncRNAs in TC have yet to be fully elucidated. The present study investigated whether LINC01420 was upregulated in TC tissues, compared with normal thyroid tissues, and the results suggested that LINC01420 may play a regulatory role in TC. Bioinformatics analysis demonstrated that LINC01420 was associated with translation, rRNA processing, mRNA splicing, regulation of transcription, DNA repair and double-strand break repair. Furthermore, the exact role of LINC01420 in TC was explored by performing a loss-of-function assay, which revealed that the knockdown of LINC01420 inhibited TC cell proliferation and cell cycle progression. The findings of the present study provide a novel insight into the molecular mechanisms underlying TC development. Moreover, they suggest that LINC01420 may serve as a potential therapeutic target for the treatment of TC, and that increased LINC01420 expression levels show potential as a prognostic marker for the disease.
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spelling pubmed-69241092020-01-02 Expression and function of long non-coding RNA LINC01420 in thyroid cancer Luo, Jin-Zhu Qin, Lu Zhang, Ling-Jie Oncol Lett Articles The Human Genome Project revealed that >90% of the human genome was found to transcribe non-coding RNAs, including micro RNAs and long non-coding RNAs (lncRNAs). lncRNAs have been identified to play a crucial role in cancer progression. Thyroid cancer (TC) is a common type of endocrine cancer; however, the functional roles of lncRNAs in TC have yet to be fully elucidated. The present study investigated whether LINC01420 was upregulated in TC tissues, compared with normal thyroid tissues, and the results suggested that LINC01420 may play a regulatory role in TC. Bioinformatics analysis demonstrated that LINC01420 was associated with translation, rRNA processing, mRNA splicing, regulation of transcription, DNA repair and double-strand break repair. Furthermore, the exact role of LINC01420 in TC was explored by performing a loss-of-function assay, which revealed that the knockdown of LINC01420 inhibited TC cell proliferation and cell cycle progression. The findings of the present study provide a novel insight into the molecular mechanisms underlying TC development. Moreover, they suggest that LINC01420 may serve as a potential therapeutic target for the treatment of TC, and that increased LINC01420 expression levels show potential as a prognostic marker for the disease. D.A. Spandidos 2020-01 2019-11-11 /pmc/articles/PMC6924109/ /pubmed/31897152 http://dx.doi.org/10.3892/ol.2019.11076 Text en Copyright: © Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Luo, Jin-Zhu
Qin, Lu
Zhang, Ling-Jie
Expression and function of long non-coding RNA LINC01420 in thyroid cancer
title Expression and function of long non-coding RNA LINC01420 in thyroid cancer
title_full Expression and function of long non-coding RNA LINC01420 in thyroid cancer
title_fullStr Expression and function of long non-coding RNA LINC01420 in thyroid cancer
title_full_unstemmed Expression and function of long non-coding RNA LINC01420 in thyroid cancer
title_short Expression and function of long non-coding RNA LINC01420 in thyroid cancer
title_sort expression and function of long non-coding rna linc01420 in thyroid cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924109/
https://www.ncbi.nlm.nih.gov/pubmed/31897152
http://dx.doi.org/10.3892/ol.2019.11076
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