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FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma
Fibrinogen C domain-containing 1 (FIBCD1) is an acetyl-recognition receptor that affects the occurrence and development of certain tumors. However, the prognostic significance of FIBCD1 in hepatocellular carcinoma (HCC) remains unclear. This study aimed to explore FIBCD1 expression in HCC and to det...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924150/ https://www.ncbi.nlm.nih.gov/pubmed/31897196 http://dx.doi.org/10.3892/ol.2019.11183 |
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author | Wang, Yan Sun, Mengjing Liu, Jibin Liu, Ying Jiang, Chunyi Zhu, Huijun Wang, Wei Wang, Yao |
author_facet | Wang, Yan Sun, Mengjing Liu, Jibin Liu, Ying Jiang, Chunyi Zhu, Huijun Wang, Wei Wang, Yao |
author_sort | Wang, Yan |
collection | PubMed |
description | Fibrinogen C domain-containing 1 (FIBCD1) is an acetyl-recognition receptor that affects the occurrence and development of certain tumors. However, the prognostic significance of FIBCD1 in hepatocellular carcinoma (HCC) remains unclear. This study aimed to explore FIBCD1 expression in HCC and to determine the prognostic value of FIBCD1 in patients with HCC. A total of 1,058 liver tissue samples with detailed and complete clinical information were collected, including 495 HCC samples. Tissue microarray immunohistochemistry analysis was used to evaluate FIBCD1 protein expression in the collected tissues. The Kaplan-Meier plotter online tool was used to investigate the association between FIBCD1 expression and prognosis of patients with HCC. Oncomine and the Gene Expression Profiling Interactive Analysis database were used for bioinformatics analysis of FIBCD1. Results showed that FIBCD1 expression was higher in HCC and was associated with tumor diameter (P=0.002), tumor number (P=0.001), tumor node metastasis stage (P<0.001), primary tumor (T; P<0.001), lymph node metastases (N; P=0.002), distant metastases (M; P=0.023), differentiation degree (P=0.003), vascular invasion (P<0.001) and liver cirrhosis (P=0.011). Patients with HCC and high FIBCD1 expression had worse overall survival than those with low FIBCD1 expression. High FIBCD1 expression (P<0.001), TNM stage (P=0.003), T (P<0.001), N (P=0.014), and vascular invasion (P<0.001) were independent prognostic factors in HCC. Hence, FIBCD1 may be a novel biomarker for prognosis evaluation of HCC. |
format | Online Article Text |
id | pubmed-6924150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-69241502020-01-02 FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma Wang, Yan Sun, Mengjing Liu, Jibin Liu, Ying Jiang, Chunyi Zhu, Huijun Wang, Wei Wang, Yao Oncol Lett Articles Fibrinogen C domain-containing 1 (FIBCD1) is an acetyl-recognition receptor that affects the occurrence and development of certain tumors. However, the prognostic significance of FIBCD1 in hepatocellular carcinoma (HCC) remains unclear. This study aimed to explore FIBCD1 expression in HCC and to determine the prognostic value of FIBCD1 in patients with HCC. A total of 1,058 liver tissue samples with detailed and complete clinical information were collected, including 495 HCC samples. Tissue microarray immunohistochemistry analysis was used to evaluate FIBCD1 protein expression in the collected tissues. The Kaplan-Meier plotter online tool was used to investigate the association between FIBCD1 expression and prognosis of patients with HCC. Oncomine and the Gene Expression Profiling Interactive Analysis database were used for bioinformatics analysis of FIBCD1. Results showed that FIBCD1 expression was higher in HCC and was associated with tumor diameter (P=0.002), tumor number (P=0.001), tumor node metastasis stage (P<0.001), primary tumor (T; P<0.001), lymph node metastases (N; P=0.002), distant metastases (M; P=0.023), differentiation degree (P=0.003), vascular invasion (P<0.001) and liver cirrhosis (P=0.011). Patients with HCC and high FIBCD1 expression had worse overall survival than those with low FIBCD1 expression. High FIBCD1 expression (P<0.001), TNM stage (P=0.003), T (P<0.001), N (P=0.014), and vascular invasion (P<0.001) were independent prognostic factors in HCC. Hence, FIBCD1 may be a novel biomarker for prognosis evaluation of HCC. D.A. Spandidos 2020-01 2019-12-04 /pmc/articles/PMC6924150/ /pubmed/31897196 http://dx.doi.org/10.3892/ol.2019.11183 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Yan Sun, Mengjing Liu, Jibin Liu, Ying Jiang, Chunyi Zhu, Huijun Wang, Wei Wang, Yao FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
title | FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
title_full | FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
title_fullStr | FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
title_full_unstemmed | FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
title_short | FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
title_sort | fibcd1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924150/ https://www.ncbi.nlm.nih.gov/pubmed/31897196 http://dx.doi.org/10.3892/ol.2019.11183 |
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