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A prospective observational study of the follow-up of medical management of early pregnancy failure
BACKGROUND: Medical termination for missed miscarriage with the use of 800 μg of vaginal misoprostol as a single agent is recommended as a cheap option before 14 weeks of gestation in developing countries. A few studies have looked at its efficacy. METHODS: A prospective, observational study was don...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924238/ https://www.ncbi.nlm.nih.gov/pubmed/31879649 http://dx.doi.org/10.4103/jfmpc.jfmpc_585_19 |
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author | Kumari, Pushplata Preethi, R.N. Abraham, Anuja Rathore, Swati Benjamin, Santosh Gowri, M Mathews, Jiji Elizabeth |
author_facet | Kumari, Pushplata Preethi, R.N. Abraham, Anuja Rathore, Swati Benjamin, Santosh Gowri, M Mathews, Jiji Elizabeth |
author_sort | Kumari, Pushplata |
collection | PubMed |
description | BACKGROUND: Medical termination for missed miscarriage with the use of 800 μg of vaginal misoprostol as a single agent is recommended as a cheap option before 14 weeks of gestation in developing countries. A few studies have looked at its efficacy. METHODS: A prospective, observational study was done on women having medical termination with up to three doses of 800 μg vaginal misoprostol at 12 hourly intervals. The number of women who needed check curettage was collected. Ultrasound findings if done were collated. Follow-up was done telephonically at the end of first week, fourth week and sixth week. RESULTS: The cohort comprised 145 women. The primary outcome was the need for curettage after expulsion of products following medical management and this was 49/145 (37.8%) of women. The induction expulsion interval was 36 hours. The mean endometrial thickness of the 113/145 women who had an ultrasound was 11 mm. The mean endometrial thickness in women who had check curettage was 18 mm. Persistent spotting was the only significant symptom at follow-up. Resumption of cycle at the end of the sixth week was seen in 105/132 (80.15%) of women who were followed up. CONCLUSION: Findings of our study showed the check curettage rate of 37.8%. However, the regime which we used, that is, 800 μg vaginal misoprostol at 12 hourly intervals had a long induction to expulsion interval of 36 hours. In all, 80% of women resumed normal cycles at the end of the sixth week. No significant complications were noted on follow-up. |
format | Online Article Text |
id | pubmed-6924238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-69242382019-12-26 A prospective observational study of the follow-up of medical management of early pregnancy failure Kumari, Pushplata Preethi, R.N. Abraham, Anuja Rathore, Swati Benjamin, Santosh Gowri, M Mathews, Jiji Elizabeth J Family Med Prim Care Original Article BACKGROUND: Medical termination for missed miscarriage with the use of 800 μg of vaginal misoprostol as a single agent is recommended as a cheap option before 14 weeks of gestation in developing countries. A few studies have looked at its efficacy. METHODS: A prospective, observational study was done on women having medical termination with up to three doses of 800 μg vaginal misoprostol at 12 hourly intervals. The number of women who needed check curettage was collected. Ultrasound findings if done were collated. Follow-up was done telephonically at the end of first week, fourth week and sixth week. RESULTS: The cohort comprised 145 women. The primary outcome was the need for curettage after expulsion of products following medical management and this was 49/145 (37.8%) of women. The induction expulsion interval was 36 hours. The mean endometrial thickness of the 113/145 women who had an ultrasound was 11 mm. The mean endometrial thickness in women who had check curettage was 18 mm. Persistent spotting was the only significant symptom at follow-up. Resumption of cycle at the end of the sixth week was seen in 105/132 (80.15%) of women who were followed up. CONCLUSION: Findings of our study showed the check curettage rate of 37.8%. However, the regime which we used, that is, 800 μg vaginal misoprostol at 12 hourly intervals had a long induction to expulsion interval of 36 hours. In all, 80% of women resumed normal cycles at the end of the sixth week. No significant complications were noted on follow-up. Wolters Kluwer - Medknow 2019-12-10 /pmc/articles/PMC6924238/ /pubmed/31879649 http://dx.doi.org/10.4103/jfmpc.jfmpc_585_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kumari, Pushplata Preethi, R.N. Abraham, Anuja Rathore, Swati Benjamin, Santosh Gowri, M Mathews, Jiji Elizabeth A prospective observational study of the follow-up of medical management of early pregnancy failure |
title | A prospective observational study of the follow-up of medical management of early pregnancy failure |
title_full | A prospective observational study of the follow-up of medical management of early pregnancy failure |
title_fullStr | A prospective observational study of the follow-up of medical management of early pregnancy failure |
title_full_unstemmed | A prospective observational study of the follow-up of medical management of early pregnancy failure |
title_short | A prospective observational study of the follow-up of medical management of early pregnancy failure |
title_sort | prospective observational study of the follow-up of medical management of early pregnancy failure |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924238/ https://www.ncbi.nlm.nih.gov/pubmed/31879649 http://dx.doi.org/10.4103/jfmpc.jfmpc_585_19 |
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