Cargando…

SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1

Detalles Bibliográficos
Autores principales:	Altamura, Sandro, Schaeper, Ute, Dames, Sibylle, Löffler, Kathrin, Eisermann, Mona, Frauendorf, Christian, Müdder, Katja, Neves, Joana, Muckenthaler, Martina U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2019
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924545/ https://www.ncbi.nlm.nih.gov/pubmed/31976476 http://dx.doi.org/10.1097/HS9.0000000000000301

Ejemplares similares

SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia
por: Vadolas, Jim, et al.
Publicado: (2021)

Overexpression of GalNAc-transferase GalNAc-T3 Promotes Pancreatic Cancer Cell Growth
por: Taniuchi, Keisuke, et al.
Publicado: (2011)

Expression of alpha-GalNAc glycoproteins by breast cancers.
por: Brooks, S. A., et al.
Publicado: (1995)

The GalNAc-T Activation (GALA) Pathway: Drivers and markers
por: Chia, Joanne, et al.
Publicado: (2019)

The Gal/GalNac lectin as a possible acetylcholine receptor in Entamoeba histolytica
por: Pacheco-Sánchez, Marisol, et al.
Publicado: (2023)

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
por: Brown, Christopher R, et al.
Publicado: (2020)

Molecular Recognition of GalNAc in Mucin-Type O-Glycosylation
por: Sanz-Martinez, Ignacio, et al.
Publicado: (2023)

Evidence of Gene Conversion in Genes Encoding the Gal/GalNac Lectin Complex of Entamoeba
por: Weedall, Gareth D., et al.
Publicado: (2011)

Role of GalNAc4S-6ST in Astrocytic Tumor Progression
por: Kobayashi, Tatsuya, et al.
Publicado: (2013)

Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells
por: Tsuchida, Akiko, et al.
Publicado: (2018)

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics
por: Huang, Yuanyu
Publicado: (2017)

Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
por: Wang, Shuaishuai, et al.
Publicado: (2021)

Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
por: Pedersen, Johannes W., et al.
Publicado: (2011)

The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies
por: Janas, Maja M., et al.
Publicado: (2018)

Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models
por: Kim, Youngsoo, et al.
Publicado: (2019)

Polypeptide-GalNAc-Transferase-13 Shows Prognostic Impact in Breast Cancer
por: Fernandez, Eugenia, et al.
Publicado: (2021)

A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis
por: Verzijl, Cristy R.C., et al.
Publicado: (2022)

ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs
por: Yang, Hui, et al.
Publicado: (2022)

Role of microtubule-associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's disease
por: Ma, Li, et al.
Publicado: (2019)

Fasciola hepatica Immune Regulates CD11c(+) Cells by Interacting with the Macrophage Gal/GalNAc Lectin
por: Rodríguez, Ernesto, et al.
Publicado: (2017)

CNL–Clitocybe nebularis Lectin—The Fungal GalNAcβ1-4GlcNAc-Binding Lectin
por: Sabotič, Jerica, et al.
Publicado: (2019)

ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration
por: Chia, Joanne, et al.
Publicado: (2014)

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
por: Nair, Jayaprakash K., et al.
Publicado: (2017)

GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location
por: Albuquerque, Mário S. de Souza, et al.
Publicado: (2018)

GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells
por: Sewing, Sabine, et al.
Publicado: (2018)

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor
por: Schmidt, Karsten, et al.
Publicado: (2017)

Quantification of Surface GalNAc Ligands Decorating Nanostructured Lipid Carriers by UPLC-ELSD
por: Gauthier, Laura, et al.
Publicado: (2019)

Author Correction: Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells
por: Tsuchida, Akiko, et al.
Publicado: (2020)

GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics
por: Thangamani, Lokesh, et al.
Publicado: (2021)

Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides
por: Singh, YashoNandini, et al.
Publicado: (2021)

Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs
por: Agarwal, Saket, et al.
Publicado: (2021)

O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production
por: Tachida, Yuriko, et al.
Publicado: (2023)

Role of Truncated O-GalNAc Glycans in Cancer Progression and Metastasis in Endocrine Cancers
por: Pinto, Diluka, et al.
Publicado: (2023)

Mutagenesis Studies and Structure-function Relationships for GalNAc/Gal-Specific Lectin from the Sea Mussel Crenomytilus grayanus
por: Kovalchuk, Svetlana N., et al.
Publicado: (2018)

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
por: de las Rivas, Matilde, et al.
Publicado: (2017)

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
por: Janas, Maja M., et al.
Publicado: (2018)

Polypeptide-GalNAc-T6 expression predicts better overall survival in patients with colon cancer
por: Ubillos, Luis, et al.
Publicado: (2018)

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc(3)-Conjugated 2′-MOE-ASOs
por: Shemesh, Colby S., et al.
Publicado: (2017)

Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa
por: Nygaard, Marie B., et al.
Publicado: (2018)

Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
por: Janas, Maja M, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dhhkdqnr7nb69b8f2asnvsenj0