Helicase Lymphoid-Specific Enzyme Contributes to the Maintenance of Methylation of SST1 Pericentromeric Repeats That Are Frequently Demethylated in Colon Cancer and Associate with Genomic Damage

DNA hypomethylation at repetitive elements accounts for the genome-wide DNA hypomethylation common in cancer, including colorectal cancer (CRC). We identified a pericentromeric repeat element called SST1 frequently hypomethylated (>5% demethylation compared with matched normal tissue) in several...

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Detalles Bibliográficos
Autores principales: Samuelsson, Johanna K., Dumbovic, Gabrijela, Polo, Cristian, Moreta, Cristina, Alibés, Andreu, Ruiz-Larroya, Tatiana, Giménez-Bonafé, Pepita, Alonso, Sergio, Forcales, Sonia-V., Manuel, Perucho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924650/
https://www.ncbi.nlm.nih.gov/pubmed/31867127
http://dx.doi.org/10.3390/epigenomes1010002

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