Cargando…
Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study
OBJECTIVES: To describe all iron deficiency anaemia (IDA)–related causes during follow-up of patients newly diagnosed with IDA and to assess whether a delayed colorectal cancer (CRC) diagnosis influences survival. DESIGN AND SETTING: Retrospective cohort study of patients from general practices in t...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924716/ https://www.ncbi.nlm.nih.gov/pubmed/31784447 http://dx.doi.org/10.1136/bmjopen-2019-032930 |
_version_ | 1783481772275662848 |
---|---|
author | Schop, Annemarie Stouten, Karlijn Riedl, Jurgen van Houten, Ron van Rosmalen, Joost Wolfhagen, Frank Bindels, Patrick J E Levin, Mark-David |
author_facet | Schop, Annemarie Stouten, Karlijn Riedl, Jurgen van Houten, Ron van Rosmalen, Joost Wolfhagen, Frank Bindels, Patrick J E Levin, Mark-David |
author_sort | Schop, Annemarie |
collection | PubMed |
description | OBJECTIVES: To describe all iron deficiency anaemia (IDA)–related causes during follow-up of patients newly diagnosed with IDA and to assess whether a delayed colorectal cancer (CRC) diagnosis influences survival. DESIGN AND SETTING: Retrospective cohort study of patients from general practices in the Dordrecht area, the Netherlands. PARTICIPANTS: Men and women aged ≥50 years with a new diagnosis of IDA (ie, no anaemia 2 years previously). METHOD: From February 2007 to February 2018, all relevant data were collected from the files of the referral hospital. Early IDA-related cause was defined as established within 18 weeks after IDA diagnosis. Cox proportional-hazards regression was used to analyse survival of patients with CRC diagnosis. RESULTS: 587 patients with IDA were included with a median follow-up of 4.6 years. Early and late IDA-related causes could be established in 32% and 8% of patients, respectively. Early and late CRC was found in 8% and 2% of patients, respectively, and were located mainly right sided. After adjustment for age, gender and TNM classification, mortality risk was lower in patients with IDA with early CRC diagnosis, but not significantly (HR 0.30, 95% CI 0.09 to 1.02). CONCLUSION: Even with extended follow-up, the cause of IDA remains elusive in the majority of patients with IDA in general practice. However, patients with IDA are at increased risk for in particular right-sided CRC and a late diagnosis of CRC appears to have a detrimental effect on survival in patients with IDA. |
format | Online Article Text |
id | pubmed-6924716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-69247162020-01-02 Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study Schop, Annemarie Stouten, Karlijn Riedl, Jurgen van Houten, Ron van Rosmalen, Joost Wolfhagen, Frank Bindels, Patrick J E Levin, Mark-David BMJ Open General practice / Family practice OBJECTIVES: To describe all iron deficiency anaemia (IDA)–related causes during follow-up of patients newly diagnosed with IDA and to assess whether a delayed colorectal cancer (CRC) diagnosis influences survival. DESIGN AND SETTING: Retrospective cohort study of patients from general practices in the Dordrecht area, the Netherlands. PARTICIPANTS: Men and women aged ≥50 years with a new diagnosis of IDA (ie, no anaemia 2 years previously). METHOD: From February 2007 to February 2018, all relevant data were collected from the files of the referral hospital. Early IDA-related cause was defined as established within 18 weeks after IDA diagnosis. Cox proportional-hazards regression was used to analyse survival of patients with CRC diagnosis. RESULTS: 587 patients with IDA were included with a median follow-up of 4.6 years. Early and late IDA-related causes could be established in 32% and 8% of patients, respectively. Early and late CRC was found in 8% and 2% of patients, respectively, and were located mainly right sided. After adjustment for age, gender and TNM classification, mortality risk was lower in patients with IDA with early CRC diagnosis, but not significantly (HR 0.30, 95% CI 0.09 to 1.02). CONCLUSION: Even with extended follow-up, the cause of IDA remains elusive in the majority of patients with IDA in general practice. However, patients with IDA are at increased risk for in particular right-sided CRC and a late diagnosis of CRC appears to have a detrimental effect on survival in patients with IDA. BMJ Publishing Group 2019-11-28 /pmc/articles/PMC6924716/ /pubmed/31784447 http://dx.doi.org/10.1136/bmjopen-2019-032930 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | General practice / Family practice Schop, Annemarie Stouten, Karlijn Riedl, Jurgen van Houten, Ron van Rosmalen, Joost Wolfhagen, Frank Bindels, Patrick J E Levin, Mark-David Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
title | Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
title_full | Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
title_fullStr | Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
title_full_unstemmed | Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
title_short | Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
title_sort | long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study |
topic | General practice / Family practice |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924716/ https://www.ncbi.nlm.nih.gov/pubmed/31784447 http://dx.doi.org/10.1136/bmjopen-2019-032930 |
work_keys_str_mv | AT schopannemarie longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT stoutenkarlijn longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT riedljurgen longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT vanhoutenron longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT vanrosmalenjoost longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT wolfhagenfrank longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT bindelspatrickje longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy AT levinmarkdavid longtermoutcomesinpatientsnewlydiagnosedwithirondeficiencyanaemiaingeneralpracticearetrospectivecohortstudy |