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Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study

INTRODUCTION: In the early weeks after surgery, patients may experience cognitive changes and impaired memory and concentration—changes commonly referred to as postoperative cognitive decline. It is often the patient and/or a relative that initially detects a change in cognitive capacity after surge...

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Autores principales: Nilsson, Ulrica, Liander, Karin, Rooyackers, Olav, Eriksson, Lars I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924728/
https://www.ncbi.nlm.nih.gov/pubmed/31843843
http://dx.doi.org/10.1136/bmjopen-2019-032650
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author Nilsson, Ulrica
Liander, Karin
Rooyackers, Olav
Eriksson, Lars I
author_facet Nilsson, Ulrica
Liander, Karin
Rooyackers, Olav
Eriksson, Lars I
author_sort Nilsson, Ulrica
collection PubMed
description INTRODUCTION: In the early weeks after surgery, patients may experience cognitive changes and impaired memory and concentration—changes commonly referred to as postoperative cognitive decline. It is often the patient and/or a relative that initially detects a change in cognitive capacity after surgery, typically when resuming daily activities. We lack information about how patients experience early postoperative cognition (delayed neurocognitive recovery) and if these experiences can be reflected in biochemical pattern of inflammatory signalling molecules, cognitive function as well as on quality of postoperative recovery. METHODS AND ANALYSIS: The study has a mixed-methods design that is integration of qualitative and quantitative data within a single investigation. Participants included will be patients aged ≥60 years that are undergoing major elective joint replacement surgery (n=40) and their relative. Patient’s experience of his/her early cognition will be captured by interviews on postoperative day 13–16 during the follow-up visit. A relative will also be interviewed on the same day or the day after. Cognitive function will be measured preoperatively and on postoperative day 13–16 using the International Study Group of Postoperative Cognitive Dysfunction test battery. Symptoms/discomfort will be measured preoperatively and postoperatively (on postoperative day 1 and 2 and at the follow-up visit day 13–16) by the Swedish version of Quality of Recovery and by a visual analogue scale assessing pain intensity. Biomarkers will also be collected at the same time points. The findings from the interviews will be sorted out depending on group stratification (no delayed neurocognitive recovery and delayed neurocognitive recovery). The qualitative and quantitative findings will be compared to seek for similarities and differences. ETHICS AND DISSEMINATION: The project has been approved by the Swedish Ethical Review Authority (2019–02968) and will follow the principles outlined in the 1964 Helsinki Declaration and its later amendments. Results from this study will be disseminated in peer-reviewed journals, scientific conferences and in social media.
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spelling pubmed-69247282020-01-02 Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study Nilsson, Ulrica Liander, Karin Rooyackers, Olav Eriksson, Lars I BMJ Open Anaesthesia INTRODUCTION: In the early weeks after surgery, patients may experience cognitive changes and impaired memory and concentration—changes commonly referred to as postoperative cognitive decline. It is often the patient and/or a relative that initially detects a change in cognitive capacity after surgery, typically when resuming daily activities. We lack information about how patients experience early postoperative cognition (delayed neurocognitive recovery) and if these experiences can be reflected in biochemical pattern of inflammatory signalling molecules, cognitive function as well as on quality of postoperative recovery. METHODS AND ANALYSIS: The study has a mixed-methods design that is integration of qualitative and quantitative data within a single investigation. Participants included will be patients aged ≥60 years that are undergoing major elective joint replacement surgery (n=40) and their relative. Patient’s experience of his/her early cognition will be captured by interviews on postoperative day 13–16 during the follow-up visit. A relative will also be interviewed on the same day or the day after. Cognitive function will be measured preoperatively and on postoperative day 13–16 using the International Study Group of Postoperative Cognitive Dysfunction test battery. Symptoms/discomfort will be measured preoperatively and postoperatively (on postoperative day 1 and 2 and at the follow-up visit day 13–16) by the Swedish version of Quality of Recovery and by a visual analogue scale assessing pain intensity. Biomarkers will also be collected at the same time points. The findings from the interviews will be sorted out depending on group stratification (no delayed neurocognitive recovery and delayed neurocognitive recovery). The qualitative and quantitative findings will be compared to seek for similarities and differences. ETHICS AND DISSEMINATION: The project has been approved by the Swedish Ethical Review Authority (2019–02968) and will follow the principles outlined in the 1964 Helsinki Declaration and its later amendments. Results from this study will be disseminated in peer-reviewed journals, scientific conferences and in social media. BMJ Publishing Group 2019-12-15 /pmc/articles/PMC6924728/ /pubmed/31843843 http://dx.doi.org/10.1136/bmjopen-2019-032650 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Anaesthesia
Nilsson, Ulrica
Liander, Karin
Rooyackers, Olav
Eriksson, Lars I
Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
title Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
title_full Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
title_fullStr Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
title_full_unstemmed Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
title_short Patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
title_sort patients’ experiences of early postoperative cognition and its relation to cognitive decline and inflammatory responses: a protocol for a mixed-methods study
topic Anaesthesia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924728/
https://www.ncbi.nlm.nih.gov/pubmed/31843843
http://dx.doi.org/10.1136/bmjopen-2019-032650
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