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Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype

Genes with similar roles in the cell cluster on chromosomes, thus benefiting from coordinated regulation. This allows gene function to be inferred by transferring annotations from genomic neighbors, following the guilt-by-association principle. We performed a systematic search for co-occurrence of &...

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Detalles Bibliográficos
Autores principales: Mihelčić, Matej, Šmuc, Tomislav, Supek, Fran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925100/
https://www.ncbi.nlm.nih.gov/pubmed/31863070
http://dx.doi.org/10.1038/s41598-019-55984-0