LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer

Triple-negative breast cancer (TNBC) is a highly aggressive subtype that is untreatable with hormonal or HER2-targeted therapies and is also typically unresponsive to checkpoint-blockade immunotherapy. Within the tumor microenvironment dysregulated immune cell metabolism has emerged as a key mechani...

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Detalles Bibliográficos
Autores principales: Carpenter, Katherine J., Valfort, Aurore-Cecile, Steinauer, Nick, Chatterjee, Arindam, Abuirqeba, Suomia, Majidi, Shabnam, Sengupta, Monideepa, Di Paolo, Richard J., Shornick, Laurie P., Zhang, Jinsong, Flaveny, Colin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925117/
https://www.ncbi.nlm.nih.gov/pubmed/31863071
http://dx.doi.org/10.1038/s41598-019-56038-1

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