Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map these lesions genome-wide with nucleotide-level precision are limited. Here, we present a method, termed SSiNGLe, and demonstrate its utility to explore the distribution and dynamic changes in genome-wide SSBs...

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Detalles Bibliográficos
Autores principales: Cao, Huifen, Salazar-García, Lorena, Gao, Fan, Wahlestedt, Thor, Wu, Chun-Lin, Han, Xueer, Cai, Ye, Xu, Dongyang, Wang, Fang, Tang, Lu, Ricciardi, Natalie, Cai, DingDing, Wang, Huifang, Chin, Mario P. S., Timmons, James A., Wahlestedt, Claes, Kapranov, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925131/
https://www.ncbi.nlm.nih.gov/pubmed/31862872
http://dx.doi.org/10.1038/s41467-019-13602-7

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