RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers

The development of triple-negative breast cancer (TNBC) negatively impacts both quality of life and survival in a high percentage of patients. Here, we show that RING finger protein 208 (RNF208) decreases the stability of soluble Vimentin protein through a polyubiquitin-mediated proteasomal degradat...

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Detalles Bibliográficos
Autores principales: Pang, Kyoungwha, Park, Jinah, Ahn, Sung Gwe, Lee, Jihee, Park, Yuna, Ooshima, Akira, Mizuno, Seiya, Yamashita, Satoshi, Park, Kyung-Soon, Lee, So-Young, Jeong, Joon, Ushijima, Toshikazu, Yang, Kyung-Min, Kim, Seong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925134/
https://www.ncbi.nlm.nih.gov/pubmed/31862882
http://dx.doi.org/10.1038/s41467-019-13852-5

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