A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods...

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Detalles Bibliográficos
Autores principales: Chiba, Shuntaro, Ohue, Masahito, Gryniukova, Anastasiia, Borysko, Petro, Zozulya, Sergey, Yasuo, Nobuaki, Yoshino, Ryunosuke, Ikeda, Kazuyoshi, Shin, Woong-Hee, Kihara, Daisuke, Iwadate, Mitsuo, Umeyama, Hideaki, Ichikawa, Takaaki, Teramoto, Reiji, Hsin, Kun-Yi, Gupta, Vipul, Kitano, Hiroaki, Sakamoto, Mika, Higuchi, Akiko, Miura, Nobuaki, Yura, Kei, Mochizuki, Masahiro, Ramakrishnan, Chandrasekaran, Thangakani, A. Mary, Velmurugan, D., Gromiha, M. Michael, Nakane, Itsuo, Uchida, Nanako, Hakariya, Hayase, Tan, Modong, Nakamura, Hironori K., Suzuki, Shogo D., Ito, Tomoki, Kawatani, Masahiro, Kudoh, Kentaroh, Takashina, Sakurako, Yamamoto, Kazuki Z., Moriwaki, Yoshitaka, Oda, Keita, Kobayashi, Daisuke, Okuno, Tatsuya, Minami, Shintaro, Chikenji, George, Prathipati, Philip, Nagao, Chioko, Mohsen, Attayeb, Ito, Mari, Mizuguchi, Kenji, Honma, Teruki, Ishida, Takashi, Hirokawa, Takatsugu, Akiyama, Yutaka, Sekijima, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925144/
https://www.ncbi.nlm.nih.gov/pubmed/31863054
http://dx.doi.org/10.1038/s41598-019-55069-y

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