Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium

The aim of this study was to determine whether dietary intervention influenced luminal Ca(2+) levels and Enterococcus faecium gut colonization in mice. For this purpose, mice fed semi‐synthetic food AIN93 were compared to mice fed AIN93‐low calcium (LC). Administration of AIN93‐LC resulted in lower...

Descripción completa

Detalles Bibliográficos
Autores principales: Top, Janetta, Hendrickx, Antoni P. A., van Ampting, Marleen T. J., van Limpt, Kees, Knol, Jan, van de Kamer, Denise, Braat, Johanna C., Viveen, Marco, Rogers, Malbert R., Kemperman, Hans, Willems, Rob J. L., Paganelli, Fernanda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925158/
https://www.ncbi.nlm.nih.gov/pubmed/31568701
http://dx.doi.org/10.1002/mbo3.936
Descripción
Sumario:The aim of this study was to determine whether dietary intervention influenced luminal Ca(2+) levels and Enterococcus faecium gut colonization in mice. For this purpose, mice fed semi‐synthetic food AIN93 were compared to mice fed AIN93‐low calcium (LC). Administration of AIN93‐LC resulted in lower luminal Ca(2+) levels independent of the presence of E. faecium. Furthermore, E. faecium gut colonization was reduced in mice fed AIN93‐LC based on culture, and which was in concordance with a reduction of Enterococcaceae in microbiota analysis. In conclusion, diet intervention might be a strategy for controlling gut colonization of E. faecium, an important opportunistic nosocomial pathogen.

Ejemplares similares