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Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium

The aim of this study was to determine whether dietary intervention influenced luminal Ca(2+) levels and Enterococcus faecium gut colonization in mice. For this purpose, mice fed semi‐synthetic food AIN93 were compared to mice fed AIN93‐low calcium (LC). Administration of AIN93‐LC resulted in lower...

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Autores principales: Top, Janetta, Hendrickx, Antoni P. A., van Ampting, Marleen T. J., van Limpt, Kees, Knol, Jan, van de Kamer, Denise, Braat, Johanna C., Viveen, Marco, Rogers, Malbert R., Kemperman, Hans, Willems, Rob J. L., Paganelli, Fernanda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925158/
https://www.ncbi.nlm.nih.gov/pubmed/31568701
http://dx.doi.org/10.1002/mbo3.936
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author Top, Janetta
Hendrickx, Antoni P. A.
van Ampting, Marleen T. J.
van Limpt, Kees
Knol, Jan
van de Kamer, Denise
Braat, Johanna C.
Viveen, Marco
Rogers, Malbert R.
Kemperman, Hans
Willems, Rob J. L.
Paganelli, Fernanda L.
author_facet Top, Janetta
Hendrickx, Antoni P. A.
van Ampting, Marleen T. J.
van Limpt, Kees
Knol, Jan
van de Kamer, Denise
Braat, Johanna C.
Viveen, Marco
Rogers, Malbert R.
Kemperman, Hans
Willems, Rob J. L.
Paganelli, Fernanda L.
author_sort Top, Janetta
collection PubMed
description The aim of this study was to determine whether dietary intervention influenced luminal Ca(2+) levels and Enterococcus faecium gut colonization in mice. For this purpose, mice fed semi‐synthetic food AIN93 were compared to mice fed AIN93‐low calcium (LC). Administration of AIN93‐LC resulted in lower luminal Ca(2+) levels independent of the presence of E. faecium. Furthermore, E. faecium gut colonization was reduced in mice fed AIN93‐LC based on culture, and which was in concordance with a reduction of Enterococcaceae in microbiota analysis. In conclusion, diet intervention might be a strategy for controlling gut colonization of E. faecium, an important opportunistic nosocomial pathogen.
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spelling pubmed-69251582019-12-24 Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium Top, Janetta Hendrickx, Antoni P. A. van Ampting, Marleen T. J. van Limpt, Kees Knol, Jan van de Kamer, Denise Braat, Johanna C. Viveen, Marco Rogers, Malbert R. Kemperman, Hans Willems, Rob J. L. Paganelli, Fernanda L. Microbiologyopen Original Articles The aim of this study was to determine whether dietary intervention influenced luminal Ca(2+) levels and Enterococcus faecium gut colonization in mice. For this purpose, mice fed semi‐synthetic food AIN93 were compared to mice fed AIN93‐low calcium (LC). Administration of AIN93‐LC resulted in lower luminal Ca(2+) levels independent of the presence of E. faecium. Furthermore, E. faecium gut colonization was reduced in mice fed AIN93‐LC based on culture, and which was in concordance with a reduction of Enterococcaceae in microbiota analysis. In conclusion, diet intervention might be a strategy for controlling gut colonization of E. faecium, an important opportunistic nosocomial pathogen. John Wiley and Sons Inc. 2019-09-30 /pmc/articles/PMC6925158/ /pubmed/31568701 http://dx.doi.org/10.1002/mbo3.936 Text en © 2019 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Top, Janetta
Hendrickx, Antoni P. A.
van Ampting, Marleen T. J.
van Limpt, Kees
Knol, Jan
van de Kamer, Denise
Braat, Johanna C.
Viveen, Marco
Rogers, Malbert R.
Kemperman, Hans
Willems, Rob J. L.
Paganelli, Fernanda L.
Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium
title Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium
title_full Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium
title_fullStr Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium
title_full_unstemmed Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium
title_short Low‐calcium diet in mice leads to reduced gut colonization by Enterococcus faecium
title_sort low‐calcium diet in mice leads to reduced gut colonization by enterococcus faecium
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925158/
https://www.ncbi.nlm.nih.gov/pubmed/31568701
http://dx.doi.org/10.1002/mbo3.936
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