PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth

p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney cancer, encodes PBRM1. Here, we identify PBRM1 as a...

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Detalles Bibliográficos
Autores principales: Cai, Weijia, Su, Liya, Liao, Lili, Liu, Zongzhi Z., Langbein, Lauren, Dulaimi, Essel, Testa, Joseph R., Uzzo, Robert G., Zhong, Zhijiu, Jiang, Wei, Yan, Qin, Zhang, Qing, Yang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925188/
https://www.ncbi.nlm.nih.gov/pubmed/31863007
http://dx.doi.org/10.1038/s41467-019-13608-1

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