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Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer

Background: It is well-known that Aurora kinase A (AURKA) shows oncogenic properties in various tumor types including gastric cancer (GC). Moreover, previous studies have demonstrated that AURKA has a specific androgen receptor (AR) binding site in its promoter; thus, it could be regulated by AR. Si...

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Autores principales: Soleymani Fard, Shahrzad, Sotoudeh, Masoud, Yazdanbod, Mansour, Ghavamzadeh, Ardeshir, Malekzadeh, Reza, Yaghmaie, Marjan, Mousavi, Seyed Asadollah, Ghaffari, Seyed H., Alimoghaddam, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925368/
https://www.ncbi.nlm.nih.gov/pubmed/31871591
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author Soleymani Fard, Shahrzad
Sotoudeh, Masoud
Yazdanbod, Mansour
Ghavamzadeh, Ardeshir
Malekzadeh, Reza
Yaghmaie, Marjan
Mousavi, Seyed Asadollah
Ghaffari, Seyed H.
Alimoghaddam, Kamran
author_facet Soleymani Fard, Shahrzad
Sotoudeh, Masoud
Yazdanbod, Mansour
Ghavamzadeh, Ardeshir
Malekzadeh, Reza
Yaghmaie, Marjan
Mousavi, Seyed Asadollah
Ghaffari, Seyed H.
Alimoghaddam, Kamran
author_sort Soleymani Fard, Shahrzad
collection PubMed
description Background: It is well-known that Aurora kinase A (AURKA) shows oncogenic properties in various tumor types including gastric cancer (GC). Moreover, previous studies have demonstrated that AURKA has a specific androgen receptor (AR) binding site in its promoter; thus, it could be regulated by AR. Since it has been shown that AR overexpresses in gastric cancer (GC) as a male-predominant tumor, the goal of this study was to evaluate the association between AR and AURKA and its prognostic value in GC patients. Materials and Methods: We assessed the expression profile of AURKA in 60 fresh GC and adjacent non-tumor tissues and 50 normal gastric specimen by qRT-PCR, and investigated the association of AURKA expression with clinicopathological features. Furthermore, we evaluated possible correlation between AURKA and AR to elucidate a novel prognostic marker using Kaplan-Meier method and Cox regression model. Results: Among GC patients, 65% (39/60) overexpressed AURKA relative to normal gastric tissues. AURKA overexpression was significantly correlated with the AR overexpression in GC patients. Although AURKA expression alone was not remarkably associated with poor outcome, we provided some evidence that combined evaluation of AURKA and AR expression could independently predict survival of GC patients adjusted for other variables (HR=1.7, CI=1.314-3.833 p=0.042). Conclusion: These results indicate that AR and AURKA may crosstalk to promote GC progression. Our findings have clinical importance because they suggest simultaneous assessment of AURKA and AR expression as a novel potential prognostic marker.
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spelling pubmed-69253682019-12-23 Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer Soleymani Fard, Shahrzad Sotoudeh, Masoud Yazdanbod, Mansour Ghavamzadeh, Ardeshir Malekzadeh, Reza Yaghmaie, Marjan Mousavi, Seyed Asadollah Ghaffari, Seyed H. Alimoghaddam, Kamran Int J Hematol Oncol Stem Cell Res Original Article Background: It is well-known that Aurora kinase A (AURKA) shows oncogenic properties in various tumor types including gastric cancer (GC). Moreover, previous studies have demonstrated that AURKA has a specific androgen receptor (AR) binding site in its promoter; thus, it could be regulated by AR. Since it has been shown that AR overexpresses in gastric cancer (GC) as a male-predominant tumor, the goal of this study was to evaluate the association between AR and AURKA and its prognostic value in GC patients. Materials and Methods: We assessed the expression profile of AURKA in 60 fresh GC and adjacent non-tumor tissues and 50 normal gastric specimen by qRT-PCR, and investigated the association of AURKA expression with clinicopathological features. Furthermore, we evaluated possible correlation between AURKA and AR to elucidate a novel prognostic marker using Kaplan-Meier method and Cox regression model. Results: Among GC patients, 65% (39/60) overexpressed AURKA relative to normal gastric tissues. AURKA overexpression was significantly correlated with the AR overexpression in GC patients. Although AURKA expression alone was not remarkably associated with poor outcome, we provided some evidence that combined evaluation of AURKA and AR expression could independently predict survival of GC patients adjusted for other variables (HR=1.7, CI=1.314-3.833 p=0.042). Conclusion: These results indicate that AR and AURKA may crosstalk to promote GC progression. Our findings have clinical importance because they suggest simultaneous assessment of AURKA and AR expression as a novel potential prognostic marker. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2019-10-01 /pmc/articles/PMC6925368/ /pubmed/31871591 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Soleymani Fard, Shahrzad
Sotoudeh, Masoud
Yazdanbod, Mansour
Ghavamzadeh, Ardeshir
Malekzadeh, Reza
Yaghmaie, Marjan
Mousavi, Seyed Asadollah
Ghaffari, Seyed H.
Alimoghaddam, Kamran
Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer
title Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer
title_full Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer
title_fullStr Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer
title_full_unstemmed Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer
title_short Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer
title_sort evaluation of the association between androgen receptor and aurka and its prognostic value in gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925368/
https://www.ncbi.nlm.nih.gov/pubmed/31871591
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