Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals

Intravenous recombinant activated Factor VIIa (rFVIIa) is approved as a hemostatic agent for only a few bleeding disorders. Since the first reported case of off-label use for rFVIIa in 1999, off-label use far exceeds the use for approved conditions. The endobronchial administration of rFVIIa to cont...

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Detalles Bibliográficos
Autores principales: Diaz, Raiko, Almeida, Patricia, Alvarez, Michael, Ferrer, Gustavo, Hernandez, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Pulmonology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925373/
https://www.ncbi.nlm.nih.gov/pubmed/31890404
http://dx.doi.org/10.7759/cureus.6202
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author Diaz, Raiko
Almeida, Patricia
Alvarez, Michael
Ferrer, Gustavo
Hernandez, Felix
author_facet Diaz, Raiko
Almeida, Patricia
Alvarez, Michael
Ferrer, Gustavo
Hernandez, Felix
author_sort Diaz, Raiko
collection PubMed
description Intravenous recombinant activated Factor VIIa (rFVIIa) is approved as a hemostatic agent for only a few bleeding disorders. Since the first reported case of off-label use for rFVIIa in 1999, off-label use far exceeds the use for approved conditions. The endobronchial administration of rFVIIa to control alveolar hemorrhage has been published in only a few case reports. Herein we report a case series of endobronchial rFVIIa use for life-threatening pulmonary hemorrhage at two institutions in south Florida. 
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spelling pubmed-69253732019-12-30 Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals Diaz, Raiko Almeida, Patricia Alvarez, Michael Ferrer, Gustavo Hernandez, Felix Cureus Pulmonology Intravenous recombinant activated Factor VIIa (rFVIIa) is approved as a hemostatic agent for only a few bleeding disorders. Since the first reported case of off-label use for rFVIIa in 1999, off-label use far exceeds the use for approved conditions. The endobronchial administration of rFVIIa to control alveolar hemorrhage has been published in only a few case reports. Herein we report a case series of endobronchial rFVIIa use for life-threatening pulmonary hemorrhage at two institutions in south Florida.  Cureus 2019-11-19 /pmc/articles/PMC6925373/ /pubmed/31890404 http://dx.doi.org/10.7759/cureus.6202 Text en Copyright © 2019, Diaz et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pulmonology
Diaz, Raiko
Almeida, Patricia
Alvarez, Michael
Ferrer, Gustavo
Hernandez, Felix
Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals
title Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals
title_full Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals
title_fullStr Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals
title_full_unstemmed Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals
title_short Life-Threatening Pulmonary Hemorrhage Responds to Recombinant Factor VIIa: A Case Series in South Florida Hospitals
title_sort life-threatening pulmonary hemorrhage responds to recombinant factor viia: a case series in south florida hospitals
topic Pulmonology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925373/
https://www.ncbi.nlm.nih.gov/pubmed/31890404
http://dx.doi.org/10.7759/cureus.6202
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