Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology

Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and regulator of lysosomal function. A single mutation in the human GRN gene resulting in reduced PGRN expression cause...

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Detalles Bibliográficos
Autores principales: Mendsaikhan, Anarmaa, Tooyama, Ikuo, Bellier, Jean-Pierre, Serrano, Geidy E., Sue, Lucia I., Lue, Lih-Fen, Beach, Thomas G., Walker, Douglas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925443/
https://www.ncbi.nlm.nih.gov/pubmed/31864418
http://dx.doi.org/10.1186/s40478-019-0862-8

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