Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

BACKGROUND: Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodies (MoAbs) attenuates HDM-induced allergic responses. METHODS: Two anti-Decti...

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Detalles Bibliográficos
Autores principales: Chen, Ming-Han, Huang, Ming-Ting, Yu, Wen-Kuang, Lee, Shinn-Shing, Wang, Jia-Horng, Cheng, Ting-Jen R., Bowman, Michael R., Hsieh, Shie-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925444/
https://www.ncbi.nlm.nih.gov/pubmed/31861989
http://dx.doi.org/10.1186/s12929-019-0598-6

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