Cargando…
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson’s disease, a considerable amount of work has gone into uncovering its basic cellular function. This effort has led to the implication of LRRK2 in a bewildering range of cell...
Autores principales: | Berwick, Daniel C., Heaton, George R., Azeggagh, Sonia, Harvey, Kirsten |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925518/ https://www.ncbi.nlm.nih.gov/pubmed/31864390 http://dx.doi.org/10.1186/s13024-019-0344-2 |
Ejemplares similares
-
Common themes in PrP signaling: the Src remains the same
por: Ochs, Katharina, et al.
Publicado: (2014) -
LRRK2: an éminence grise of Wnt-mediated neurogenesis?
por: Berwick, Daniel C., et al.
Publicado: (2013) -
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
por: Berwick, Daniel C., et al.
Publicado: (2012) -
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling
por: Berwick, Daniel C., et al.
Publicado: (2017) -
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity
por: Nixon-Abell, Jonathon, et al.
Publicado: (2016)