Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), is associated with exacerba...

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Detalles Bibliográficos
Autores principales: Hesse, Raphael, Hurtado, Maica Llavero, Jackson, Rosemary J., Eaton, Samantha L., Herrmann, Abigail G., Colom-Cadena, Marti, Tzioras, Makis, King, Declan, Rose, Jamie, Tulloch, Jane, McKenzie, Chris-Anne, Smith, Colin, Henstridge, Christopher M., Lamont, Douglas, Wishart, Thomas M., Spires-Jones, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925519/
https://www.ncbi.nlm.nih.gov/pubmed/31862015
http://dx.doi.org/10.1186/s40478-019-0847-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925519/
https://www.ncbi.nlm.nih.gov/pubmed/31862015
http://dx.doi.org/10.1186/s40478-019-0847-7

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