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Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
BACKGROUND: There has been limited evidence about frailty in older patients with acute coronary syndrome (ACS) in Vietnam. AIM: (1) To investigate the prevalence of frailty in older patients hospitalised with ACS and its associated factors; (2) To investigate the impact of frailty on percutaneous co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925543/ https://www.ncbi.nlm.nih.gov/pubmed/31908432 http://dx.doi.org/10.2147/CIA.S234597 |
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author | Nguyen, Tan Van Le, Duong Tran, Khuong Dang Bui, Khai Xuan Nguyen, Tu Ngoc |
author_facet | Nguyen, Tan Van Le, Duong Tran, Khuong Dang Bui, Khai Xuan Nguyen, Tu Ngoc |
author_sort | Nguyen, Tan Van |
collection | PubMed |
description | BACKGROUND: There has been limited evidence about frailty in older patients with acute coronary syndrome (ACS) in Vietnam. AIM: (1) To investigate the prevalence of frailty in older patients hospitalised with ACS and its associated factors; (2) To investigate the impact of frailty on percutaneous coronary intervention (PCI) and adverse outcomes in this population. METHODS: Patients aged ≥60 with ACS admitted to two teaching hospitals in Vietnam were recruited from 9/2017 to 4/2018. Frailty was defined by the Reported Edmonton Frail Scale. Multivariate logistic regression was applied to investigate the associated factors of frailty and the impact of frailty on PCI and adverse outcomes. RESULTS: There were 324 participants, mean age 73.5±8.3, 39.2% female. The prevalence of frailty was 48.1%. Advanced age, female gender, history of hypertension, heart failure, stroke and chronic kidney disease were significantly associated with a frailty status. Overall, 50.3% of the participants received PCI (58.3% in the non-frail vs 41.7% in the frail, p=0.003). However, frailty did not have an independent impact on PCI (adjusted OR 0.66, 95% CI 0.41–1.08). Frailty was significantly associated with increased risk of having arrhythmia during hospitalisation (adjusted OR 2.24, 95% CI 1.32–3.80), hospital-acquired pneumonia (adjusted OR 2.27, 95% CI 1.24–4.17), in-hospital mortality (adjusted OR 3.02, 95% CI 1.35–6.75), 30-day mortality (adjusted OR 3.28, 95% CI 1.59–6.76), and 30-day readmission (adjusted OR 2.53, 95% CI 1.38–4.63). CONCLUSION: In this study, frailty was present in nearly half of older patients with ACS and was associated with increased adverse outcomes. These findings suggest that frailty screening should be performed in older patients with ACS in Vietnam. |
format | Online Article Text |
id | pubmed-6925543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-69255432020-01-06 Frailty in Older Patients with Acute Coronary Syndrome in Vietnam Nguyen, Tan Van Le, Duong Tran, Khuong Dang Bui, Khai Xuan Nguyen, Tu Ngoc Clin Interv Aging Original Research BACKGROUND: There has been limited evidence about frailty in older patients with acute coronary syndrome (ACS) in Vietnam. AIM: (1) To investigate the prevalence of frailty in older patients hospitalised with ACS and its associated factors; (2) To investigate the impact of frailty on percutaneous coronary intervention (PCI) and adverse outcomes in this population. METHODS: Patients aged ≥60 with ACS admitted to two teaching hospitals in Vietnam were recruited from 9/2017 to 4/2018. Frailty was defined by the Reported Edmonton Frail Scale. Multivariate logistic regression was applied to investigate the associated factors of frailty and the impact of frailty on PCI and adverse outcomes. RESULTS: There were 324 participants, mean age 73.5±8.3, 39.2% female. The prevalence of frailty was 48.1%. Advanced age, female gender, history of hypertension, heart failure, stroke and chronic kidney disease were significantly associated with a frailty status. Overall, 50.3% of the participants received PCI (58.3% in the non-frail vs 41.7% in the frail, p=0.003). However, frailty did not have an independent impact on PCI (adjusted OR 0.66, 95% CI 0.41–1.08). Frailty was significantly associated with increased risk of having arrhythmia during hospitalisation (adjusted OR 2.24, 95% CI 1.32–3.80), hospital-acquired pneumonia (adjusted OR 2.27, 95% CI 1.24–4.17), in-hospital mortality (adjusted OR 3.02, 95% CI 1.35–6.75), 30-day mortality (adjusted OR 3.28, 95% CI 1.59–6.76), and 30-day readmission (adjusted OR 2.53, 95% CI 1.38–4.63). CONCLUSION: In this study, frailty was present in nearly half of older patients with ACS and was associated with increased adverse outcomes. These findings suggest that frailty screening should be performed in older patients with ACS in Vietnam. Dove 2019-12-17 /pmc/articles/PMC6925543/ /pubmed/31908432 http://dx.doi.org/10.2147/CIA.S234597 Text en © 2019 Nguyen et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Nguyen, Tan Van Le, Duong Tran, Khuong Dang Bui, Khai Xuan Nguyen, Tu Ngoc Frailty in Older Patients with Acute Coronary Syndrome in Vietnam |
title | Frailty in Older Patients with Acute Coronary Syndrome in Vietnam |
title_full | Frailty in Older Patients with Acute Coronary Syndrome in Vietnam |
title_fullStr | Frailty in Older Patients with Acute Coronary Syndrome in Vietnam |
title_full_unstemmed | Frailty in Older Patients with Acute Coronary Syndrome in Vietnam |
title_short | Frailty in Older Patients with Acute Coronary Syndrome in Vietnam |
title_sort | frailty in older patients with acute coronary syndrome in vietnam |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925543/ https://www.ncbi.nlm.nih.gov/pubmed/31908432 http://dx.doi.org/10.2147/CIA.S234597 |
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