Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery

In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility of CUR. The structure of BCSC was confirmed using (1)H-NMR. In C...

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Detalles Bibliográficos
Autores principales: Cheng, Ziting, Zhang, Wei, Hou, Xiaoya, Wang, Bingjie, Zhu, Yanping, Zhang, Peng, Zhao, Feng, Chen, Daquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925613/
https://www.ncbi.nlm.nih.gov/pubmed/31865462
http://dx.doi.org/10.1186/s11671-019-3207-4
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author Cheng, Ziting
Zhang, Wei
Hou, Xiaoya
Wang, Bingjie
Zhu, Yanping
Zhang, Peng
Zhao, Feng
Chen, Daquan
author_facet Cheng, Ziting
Zhang, Wei
Hou, Xiaoya
Wang, Bingjie
Zhu, Yanping
Zhang, Peng
Zhao, Feng
Chen, Daquan
author_sort Cheng, Ziting
collection PubMed
description In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility of CUR. The structure of BCSC was confirmed using (1)H-NMR. In CUR-BCSC@PCs with an average hydrodynamic diameter of 160.3 ± 9.0 nm, the biomimetic protein corona gave the nanoparticles excellent stability and the potential to avoid protein adsorption in blood circulation. The in vitro release experiment verified that CUR-BCSC@PCs with redox responsive shells were sensitive to high concentrations of glutathione. In addition, CUR-BCSC@PCs were effective at increasing the inhibitory activity on the proliferation of A549 cells by enhancing the intracellular uptake of CUR. These results indicated that CUR-BCSC@PCs have great application prospects in cancer therapy as effective drug delivery carriers.
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spelling pubmed-69256132020-01-03 Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery Cheng, Ziting Zhang, Wei Hou, Xiaoya Wang, Bingjie Zhu, Yanping Zhang, Peng Zhao, Feng Chen, Daquan Nanoscale Res Lett Nano Express In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility of CUR. The structure of BCSC was confirmed using (1)H-NMR. In CUR-BCSC@PCs with an average hydrodynamic diameter of 160.3 ± 9.0 nm, the biomimetic protein corona gave the nanoparticles excellent stability and the potential to avoid protein adsorption in blood circulation. The in vitro release experiment verified that CUR-BCSC@PCs with redox responsive shells were sensitive to high concentrations of glutathione. In addition, CUR-BCSC@PCs were effective at increasing the inhibitory activity on the proliferation of A549 cells by enhancing the intracellular uptake of CUR. These results indicated that CUR-BCSC@PCs have great application prospects in cancer therapy as effective drug delivery carriers. Springer US 2019-12-21 /pmc/articles/PMC6925613/ /pubmed/31865462 http://dx.doi.org/10.1186/s11671-019-3207-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Cheng, Ziting
Zhang, Wei
Hou, Xiaoya
Wang, Bingjie
Zhu, Yanping
Zhang, Peng
Zhao, Feng
Chen, Daquan
Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery
title Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery
title_full Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery
title_fullStr Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery
title_full_unstemmed Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery
title_short Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery
title_sort synthesis, characterization, and evaluation of redox-sensitive chitosan oligosaccharide nanoparticles coated with phycocyanin for drug delivery
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925613/
https://www.ncbi.nlm.nih.gov/pubmed/31865462
http://dx.doi.org/10.1186/s11671-019-3207-4
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